RSS Feed
  1. Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA
    Wang, W., P.V. Taufalele, M. Millet, K. Homsy, K. Smart, E.D. Berestesky, C.T. Schunk, M.M. Rowe, F. Bordeleau, C.A. Reinhart-King
    Cell Reports, 2023, 42: 112338.
  2. Matrix stiffness induces epithelial-to-mesenchymal transition via Piezo1-regulated calcium flux in prostate cancer cells.
    Lopez-Cavestany, M., S.B. Hahn, J.M. Hope, N.T. Reckhorn, J.D. Greenlee, S.C. Schwager, J.A. VanderBurgh, C.A. Reinhart-King, M.R. King
    iScience, 2023, 26: 106275.
  3. Analysis of Energy-Driven Leader-Follower Hierarchy During Collective Cancer Cell Invasion.
    Zhang, J., C.A. Reinhart-King
    Cell Migration in Three Dimensions, 2023, 247-262.
  4. Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis.
    Schwager, S.C., K.M. Young, L.A. Hapach, C.M. Carlson, J.A. Mosier, T.J. McArdle, W. Wang, C. Schunk, A.L. Jayathilake, M.E. Bates, F. Bordeleua, M.A. Antonyak, R.A. Cerione, C.A. Reinhart-King
    eLife, 2022, 11: e74433.
  5. Lysyl oxidase-like 1 deficiency alters ultrastructural and biomechanical properties of the peripapillary sclera in mice.
    Wareham, L.K., J. Kuchtey, H-J. Wu, E. Krystofiak, Y. Wu, C.A. Reinhart-King, R.W. Kuchtey
    Matrix Biology Plus, 2022, 16: 100120.
  6. Diabetic hyperglycemia promotes primary tumor progression through glycation-induced tumor extracellular matrix stiffening.
    Wang, W., L.A. Hapach, L. Griggs, K. Smart, Y. Wu, P.V. Taufalele, M.M. Rowe, K.M. Young, M.E. Bates, A.C. Johnson, N.J. Ferrell, A. Pozzi, C.A. Reinhart-King
    Science Advances, 2022, 8(46): eabo1673.
  7. AGE-breaker ALT711 reverses glycation-mediated cancer cell migration.
    Rowe, M.M., W. Wang, P.V. Taufalele, C.A. Reinhart-King
    Soft Matter, 2022, 18(44): 8504-8513.
  8. Link between glucose metabolism and epithelial-to-mesenchymal transition drives triple-negative breast cancer migratory heterogeneity.
    Schwager, S.C., J.A. Mosier, R.S. Padmanabhan, A. White, Q. Xing, L.A. Hapach, P.V. Taufalele, I. Ortiz, C.A. Reinhart-King
    iScience, 2022, 25(10): 105190.
  9. Phenotypic heterogeneity and cooperation in the metastatic cascade.
    Young, K.M., C.A. Reinhart-King
    Oncoscience, 2022, 9: 55-56.
  10. The Nucleus Bypasses Obstacles by Deforming Like a Drop with Surface Tension Mediated by Lamin A/C.
    Katiyar, A., J. Zhang, J.D. Antani, Y. Yu, K.L. Scott, P.P. Lele, C.A. Reinhart-King, N.J. Sniadecki, K.J. Roux, R.B. Dickinson, T.P. Lele
    Advanced Science, 2022, 9(23): 2201248.
  11. Tissue density in the progression of breast cancer: Bedside to bench and back again.
    Fabiano, E., J. Zhang, C.A. Reinhart-King
    Current Opionion in Biomedical Engineering, 2022, 100383.
  12. Highly motile cells are metabolically responsive to collagen density.
    Zanotelli, M.R., J. Zhang, I. Ortiz, C.A. Reinhart-King
    Proceedings of teh National Academy of Sciences, 2022, 119(18): e2114672119.
  13. Matrix stiffness enhances cancer-macrophage interactions and M2-like macrophage accumulation in the breast tumor microenvironment.
    Taufalele, P.V., W. Wang, A.J. Simmons, A.N. Southard-Smith, B. Chen, J.D. Greenlee, M.R. King, K.S. Lau, D.C. Hassane, F. Bordeleau, C.A. Reinhart-King
    Acta Biomaterialia, 2022, .
  14. Fluid shear stress enhances T cell activation through Piezo1.
    Hope, J.M., J.A. Dombroski, R.S. Pereles, M. Lopez-Cavestany, J.D. Greenlee, S.C. Schwager, C.A. Reinhart-King, M.R. King
    BMC Biology, 2022, 20(1): 61.
  15. Matrix stiffness primes cells for future oxidative stress.
    Taufalele, P.V., C.A. Reinhart-King
    Trends in Cancer, 2021, 7(10): 883-885.
  16. Cancer cell metabolic plasticity in migration and metastasis.
    Mosier, J.A., S.C. Schwager, D.A. Boyajian, C.A. Reinhart-King
    Clinical and Experimental Metastasis, 2021, 38(4): 343-359.
  17. Mechanoresponsive metabolism in cancer cell migration and metastasis.
    Zanotelli, M.R., J. Zhang, C.A. Reinhart-King
    Cell Metabolism, 2021, 33(7): 1307-1321.
  18. Phenotypic Heterogeneity and Metastasis of Breast Cancer Cells.
    Hapach, L.A., S.P. Carey, S.C. Schwager, P.V. Taufalele, W. Wang, J.A. Mosier, N. Ortiz-Otero, T.J. McArdle, Z.E. Goldblatt, M.C. Lampi, F. Bordeleau, J.R. Marshall, I.M. Richardson, J. Li, M.R. King, C.A. Reinhart-King
    Cancer Research, 2021, 81(13): 3649-3663.
  19. Matrix-driven changes in metabolism support cytoskeletal activity to promote cell migration.
    Wu, Y., M.R. Zanotelli, J. Zhang, C.A. Reinhart-King
    Biophsical Journal, 2021, 120(9): 1705-1717.
  20. Taxanes Sensitize Prostate Cancer Cells to TRAIL-Induced Apoptotic Synergy via Endoplasmic Reticulum Stress.
    Grayson, K.A., J.M. Hope, W. Wang, C.A. Reinhart-King, M.R. King
    Molecular Cancer Therapeutics, 2021, 20(5): 833-845.
  21. Recent advances in understanding the role of metabolic heterogeneities in cell migration.
    Mosier, J.A.*, Y. Wu*, C.A. Reinhart-King
    Faculty Reviews, 2021, 10: 8.
  22. Intrastromal Injection of Hyaluronidase Alters the Structural and Biomechanical Properties of the Corneal Stroma.
    Kim, S., S.M. Thomasy, M.A.W. Bowman, V.K. Raghunathan, Y. Song, C.A. Reinhart-King, C.J. Murphy
    Translational Vision Science & Technology, 2020, 9(6): 21.
  23. High type I collagen density fails to increase breast cancer stem cell phenotype.
    Valadao, I.C., A.C.L Ralph, F. Bordeleau, L.M. Dzik, K.S.C. Borbely, M.V. Geraldo, C.A. Reinhart-King, V.M. Freitas
    PeerJ, 2020, 8: e9153.
  24. Cancer associated fibroblasts confer shear resistance to circulating tumor cells during prostate cancer metastatic progression.
    Ortiz-Otero, N., A.B. Clinch, J. Hope, W. Wang, C.A. Reinhart-King, M.R. King
    Oncotarget, 2020, 11(12): 1037.
  25. A discrete interface in matrix stiffness creates an oscillatory pattern of endothelial monolayer disruption.
    VanderBurgh, J.A., A.V. Potharazu, S.C. Schwager, C.A. Reinhart-King
    Journal of Cell Science, 2020, 133(18): jcs244533.
  26. The Physical Microenvironment of Tumors: Characterization and Clinical Impact
    Zanotelli, M.R., N.C. Chada, C.A. Johnson, C.A. Reinhart-King
    Biophysical Reviews and Letters, 2020, 15(02): 51-82.
  27. Mechanobiology of microvesicle release, uptake, and microvesicle-mediated activation.
    Schwager, S., C.A. Reinhart-King
    Current Topics in Membranes, 2020, 86: 255-78.
  28. Targeting Tissue Stiffness in Metastasis: Mechanomedicine Improves Cancer Therapy.
    Zhang, J., C.A Reinhart-King
    Cancer Cell, 2020, 37(6): 754-755.
  29. Tissue transglutaminase 2 regulates tumor cell tensional homeostasis by increasing contractility.
    Bordeleau F., W. Wang, A. Simmons, M.A. Antonyak, R.A. Cerione, C.A Reinhart-King
    Journal of Cell Science, 2020, 133(1): jcs231134.
  30. Activation of Piezo1 sensitizes cells to TRAIL-mediated apoptosis through mitochondrial outer membrane permeability.
    Hope J.M., M. Lopez-Cavestany, W. Wang, C.A. Reinhart-King, M.R. King
    Cell Death Disease, 2019, 10(11): 837.
  31. Cell focal adhesion clustering leads to decreased and homogenized basal strains
    Kohn J.C., T. Abdalrahman T, K.L. Sack, C.A. Reinhart-King, T. Franz
    Int J Numer Method Biomed Eng., 2019, 35(12): e3260.
  32. Stiffness sensing by cells
    Janmey, P.A., D. Fletcher, C.A. Reinhart-King
    Physiological Reviews, 2020, 100(2): 695-724
  33. Extent of cell confinement in microtracks affects speed and results in differential matrix strains
    Mosier, J.A.*, Rahman-Zaman, A.*, M.R. Zanotelli, J.A. VanderBurgh, F. Bordeleau, B.D. Hoffman, C.A. Reinhart-King
    Biophysical Journal, 2019, 117(9): 1692-1701.
  34. Microscale interrogation of 3D tissue mechanics
    Zhang, J., N.C. Chada, C.A. Reinhart-King
    Frontiers in Bioengineering and Biotechnology, 2019, 7: 412.
  35. Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making
    Zanotelli, M.R., A. Rahman-Zaman, J.A. Vanderburgh, P.V. Taufalele, A. Jain, D. Erickson, F. Bordeleau, C.A. Reinhart-King
    Nature Communications, 2019, 10(1): 1-12.
  36. Energetic regulation of coordinated leader–follower dynamics during collective invasion of breast cancer cells
    Zanotelli, M.R., A. Rahman-Zaman, J.A. Vanderburgh, P.V. Taufalele, A. Jain, D. Erickson, F. Bordeleau, C.A. Reinhart-King
    Proc Natl Acad Sci USA, 2019, 116(16): 7867-7872.
  37. Fiber alignment drives changes in architectural and mechanical features in collagen matrices
    Taufalele, P.V., J.A. VanderBurgh, A. Muñoz, M.R. Zanotelli, C.A. Reinhart-King
    PLoS One, 2019, 14(5): e0216537.
  38. Engineered models to parse apart the metastatic cascade
    Hapach, L.A., J.A. Mosier, W. Wang, C.A. Reinhart-King
    NPJ Precision Oncology, 2019, 3(1): 1-8.
  39. Matrix stiffness regulates microvesicle-induced fibroblast activation
    Schwager, S.C., F. Bordeleau, J. Zhang, M.A. Antonyak, R.A. Cerione, C.A. Reinhart-King
    American Journal of Physiology-Cell Physiology, 2019, 317(1): C82–C92.
  40. Cell-Cell Mechanical Communication in Cancer
    Schwager, S.C., P.V. Taufalele, C.A. Reinhart-King
    Cellular and Molecular Bioengineering, 2019, 12(1): 1–14.
    *Featured on the front cover
  41. Substrate stiffness heterogeneities disrupt endothelial barrier integrity in a micropillar model of heterogeneous vascular stiffening
    VanderBurgh, J.A., H. Hotchkiss, A. Potharazu, P.V. Taufalele, C.A. Reinhart-King
    Integrative Biology, 2018, 10(12): 734-746.
    *Featured on the front cover
  42. Mechanical forces in tumor angiogenesis
    Zanotelli, M.R., C.A. Reinhart-King
    Biomechanics in oncology, N. Kuhn, K. Konstantopoulos, D. Cheng (Eds.), Springer, 2018, 91-112.
  43. Quantitative assessment of cell contractility using polarized light microscopy
    Wang, W., J.P. Miller, S.C. Pannullo, C.A. Reinhart-King, F. Bordeleau
    Journal of biophotonics, 2018, 11(11): e201800008.
  44. Matrix stiffness regulates vascular integrity through focal adhesion kinase activity
    Wang, W., E.M. Lollis, F. Bordeleau, C.A. Reinhart-King
    The FASEB Journal, 2018, 33(1): 1199-1208.
  45. Endothelial cells on an aged subendothelial matrix display heterogeneous strain profiles in silico
    Kohn, J.C., T. Abdairahman, K. Sack, T. Frank, C.A. Reinhart-King
    Biomechanics and Modeling in Mechanobiology, 2018, 17: 1405-1414.
  46. Determining mechanical features of modulated epithelial monolayers using subnuclear particle tracking.
    Armiger, T.J., M.C. Lampi, C.A. Reinhart-King, and K.N. Dahl
    Journal of Cell Science, 2018, 131(12): jcs216010.
  47. Clinical doses of radiation reduce collagen matrix stiffness.
    Miller, J.P., B.H. Borde, F. Bordeleau, M.R. Zanotelli, D.J. LaValley, D.J. Parker, L.J. Bonassar, S.C. Pannullo, C.A. Reinhart-King
    APL Bioengineering, 2018, 2: 031901.
  48. Beneficial effects of exercise on the subendothelial matrix are short-lived.
    Kohn, J., F. Bordeleau, J.P. Miller, H. Watkins, S. Modi, J. Azar, D.A. Putnam, and C.A. Reinhart-King
    Journal of Biomechanical Engineering, 2018, 140(7): 074501
  49. Eigenstrain as a mechanical set-point of cells.
    Lin S., M.C. Lampi, C.A. Reinhart-King, G. Tsui, J. Wang, C.A. Nelson, L. Gu
    Biomechanics and Modeling in Mechanobiology, 2018, 17: 951-959
  50. Cell migration in microfabricated 3D collagen microtracks is mediated through the prometastatic protein girdin.
    Rahman-Zaman A., S. Shan, C.A. Reinhart-King
    Cellular and Molecular Bioengineering, 2018, 11(1): 1-10.
  51. The role of age-related intimal remodeling and stiffening in atherosclerosis.
    VanderBurgh J.A., C.A. Reinhart-King
    Advances in Pharmacology, 2018, 81: 365-391.
  52. Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials.
    Lampi M.C., C.A. Reinhart-King
    Science Translational Medicine, 2018, 10(422).
  53. High-fat, high-sugar diet-induced subendothelial matrix stiffening is mitigated by exercise.
    Kohn J.C., J. Azar, F. Seta, C.A. Reinhart-King
    Cardiovascular Engineering and Technology, 2018, 9(1): 84-93.
  54. Regulation of ATP utilization during metastatic cell migration by collagen architecture.
    Zanotelli M.R., Z.E. Goldblatt, J.P. Miller, F. Bordeleau, J. Li, J.A. VanderBurgh, M.C. Lampi, M.R. King, C.A. Reinhart-King
    Molecular Biology of the Cell, 2018, 29(1): 1-9.
  55. Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy.
    Mulligan JA, F. Bordeleau, C.A. Reinhart-King, S.G. Adie
    Biomedical Optics Express, 2017, 8(2): 1152-1171.
  56. Three-dimensional collagen matrix induces a mechanosensitive invasive epithelial phenotype.
    Carey S.P., K.E. Martin, C.A. Reinhart-King
    Scientific Reports, 2017, 10(7): 42088.
  57. Matrix stiffening promotes a tumor vasculature phenotype.
    Bordeleau F., B.N. Mason, E.M. Lollis, M. Mazzola, M.R. Zanotelli, S. Somasegar, J.P. Califano, C. Montague, D.J. LaValley, J. Huynh, N. Mencia-Trinchant, Y.L. Negrón Abril, D.C. Hassane, L.J. Bonassar, J.T. Butcher, R.S. Weiss, C.A. Reinhart-King
    Proc Natl Acad Sci U S A., 2017, 114(3): 492-497.
  58. Matrix stiffness enhances VEGFR-2 internalization, signaling, and proliferation in endothelial cells.
    LaValley, D.J., M.R. Zanotelli, F. Bordeleau, W. Wang, S.C. Schwager, C.A. Reinhart-King
    Convergent Science Physical Oncology, 2017, 3(4): 044001.
  59. Subcellular regulation of cancer cell mechanics.
    Zanotelli, M.R., F. Bordeleau, C.A. Reinhart-King
    Current Opinion in Biomedical Engineering, 2017, 1(1): 8-14.
    *Featured on the cover
  60. The mechanics of single cell and collective migration of tumor cells.
    Lintz, M, A. Muñoz A, C.A. Reinhart-King
    Journal of Biomechanical Engineering, 2017, 139(2).
    *Selected as an Editor's Choice
  61. Tuning cell migration: contractility as an integrator of intracellular signals from multiple cues.
    Bordeleau, F., C.A. Reinhart-King
    F1000 Research, 2016, 5. pii: F1000 Faculty Rev-1819.
  62. Local extracellular matrix alignment directs cellular protrusion dynamics and migration through Rac1 and FAK.
    Carey S.P., Z.E. Goldblatt, K.E. Martin, B. Romero, R.M. Williams, C.A. Reinhart-King
    Integrative Biology, 2016, 8(8): 821-35.
  63. Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation.
    Desrochers L.M., F. Bordeleau, C.A. Reinhart-King, R.A. Cerione, M.A. Antonyak
    Nature Communications, 2016, 7: 11958.
  64. Improving fascin inhibitors to block tumor cell migration and metastasis.
    Han S., J. Huang, B. Liu, B. Xing, F. Bordeleau, C.A. Reinhart-King, W. Li, J.J Zhang, X.Y. Huang
    Molecular Oncology, 2016, 10(7): 966-80.
  65. Mechanical heterogeneities in the subendothelial matrix develop with age and decrease with exercise.
    Kohn J.C., A. Chen, S. Cheng, D.R. Kowal, M.R. King, C.A. Reinhart-King
    Journal of Biomechanics, 2016, 49(9): 1447-1453.
  66. Vinculin regulates directionality and cell polarity in 2D, 3D matrix and 3D microtrack migration
    Rahman, A.R., S.P. Carey, C.M. Kraning-Rush, Z.E. Goldblatt, F. Bordeleau, M.C. Lampi, D.Y. Lin, A.J. Garcia and C.A. Reinhart-King Molecular Biology of the Cell, 2016, 27(9): 1431–1441.
  67. Simvastatin ameliorates matrix stiffness-mediated endothelial monolayer disruption.
    Lampi, M.C., C.J. Faber, J. Huynh, F. Bordeleau, M.R. Zanotelli, C.A. Reinhart-King
    PLoS One, 2016, 11(1): e0147033.
  68. Manipulation of in vitro collagen matrix architecture for scaffolds of improved physiological relevance.
    Hapach, L.A., J.A. VanderBurgh, J.P. Miller, C.A. Reinhart-King
    Phys Biol., 2015, 12(6): 061002.
  69. Self-assembled cationic biodegradable nanoparticles from pH-responsive amino-acid-based poly(ester urea urethane)s and their application as a drug delivery vehicle.
    He, M., A. Potuck, J.C. Kohn, K. Fung, C.A. Reinhart-King, C.C. Chu
    Biomacromolecules, 2016, 17(2): 523-37.
  70. Microvesicles released from tumor cells disrupt epithelial cell morphology and contractility.
    Bordeleau, F., B. Chan, M.A. Antonyak, M.C. Lampi, R.A. Cerione, C.A. Reinhart-King
    J Biomech, 2016, 49(8): 1272-1279
  71. The 2015 Young Innovators of Cellular and Molecular Bioengineering.
    Reinhart-King C.A., C.E. Schmidt, N.A. Peppas
    Cell Mol Bioeng., 2015, 8(3): 305-306.
  72. Tissue stiffness regulates SR protein-mediated splicing of the EDB-fibronectin isoform in tumors
    Bordeleau, F., J.P. Califano, Y.L. Negrón Abril, B.N. Mason, D.J. LaValley, S.J. Shin, R.S. Weiss and C.A. Reinhart-King
    Proc Natl Acad Sci USA, 2015, 112(27): 8314-8319. 
  73. Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization.
    Huang F-K., S. Han, B. Xing, J. Huang, B. Liu, F. Bordeleau, C.A. Reinhart-King, J.J. Zhang, and X.-Y. Huang
    Nature Communications, 2015, 6: 7465. 
  74. Probing the biophysical properties of primary breast tumor-derived fibroblasts.
    Alcoser, T.A., F. Bordeleau, S.P. Carey, M.C. Lampi, D.R. Kowal, S. Somasegar, S. Varma, S.J. Shin, and C.A. Reinhart-King
    Cellular and Molecular Bioengineering, 2015, 8(1): 76-85
  75. Age-related vascular stiffening: causes and consequences
    Kohn, J.C.*, M.C. Lampi*, C.A. Reinhart-King
    Frontiers in Genetics, 2015, 6(112): 1-17.
    (*denotes equal contribution)
  76. Biophysical induction of vascular smooth muscle cell podosomes.
    Kim, N.Y., J.C. Kohn, J. Huynh, S.P. Carey, B.N. Mason, A.G. Vouyouka, C.A. Reinhart-King
    PLoS One, 2015, 10(3): e0119008.
  77. Comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks.
    Carey S.P., A. Rahman, C.M. Kraning-Rush, B. Romero, S. Somasegar, O.M. Torre, R.M. Williams, C.A. Reinhart-King.
    Am J Physiol Cell Physiol., 2015, 308(6): C436-47.
  78. Cooperative effects of matrix stiffness and fluid shear stress on endothelial cell behavior.
    Kohn, J.C., * D.W. Zhou, * F. Bordeleau, A.L. Zhou, B.N. Mason, M.J. Mitchell, M.R. King, C.A. Reinhart-King
    Biophysical Journal, 2015, 108(3): 471-8.
    (*denotes equal contribution)
  79. The young innovators of cellular and molecular bioengineering.
    Reinhart-King, C.A., D.J. Mooney, D.V. Schaffer
    Cellular and Molecular Bioengineering, 2014, 7(3): 291-292.
  80. Matrix stiffening in the formation of blood vessels.
    LaValley, D.J. and C.A. Reinhart-King
    Advances in Regenerative Biology, 1: 25247
  81. Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro.
    van Oers, R.F., E.G. Rens, D.J. LaValley, C.A. Reinhart-King, R.M. Merks
    PLoS Computational Biology, 2014, 10(8): e1003774.
  82. A microfluidic device to select for cells based on chemotactic phenotype.
    Bajpai, S., M.J. Mitchell, M.R. King, C.A. Reinhart-King
    Technology, 2014, 2(2): 101-105.
  83. The rocky road of metastasis: the role of cytoskeletal mechanics in cell migratory response to 3D matrix topography.
    Bordeleau F., T.A. Alcoser, C.A. Reinhart-King
    Am J Physiol Cell Physiol., 2014, 306(2): C110-20.
  84. Arterial stiffening precedes systolic hypertension in diet-induced obesity
    Weisbrod, R.M., T. Shiang, T., L. Al Sayah, J.L. Fry, S. Bajpai, C.A. Reinhart-King, H.E. Lob, L. Santhanam,
    G. Mitchell, R.A. Cohen, F. Seta
    Hypertension, 2013, 62(6): 1105-10.
  85. Topographical guidance of 3D tumor cell migration at an interface of collagen densities
    Bordeleau, F., L.N. Tang and C.A. Reinhart-King
    Physical Biology, 2013, 10(6): 065004.
  86. Controlling the Mechanical Properties of Three-Dimensional Matrices via Non-Enzymatic Collagen Glycation
    Mason, B. and C.A. Reinhart-King
    Organogenesis, 2013, 9(2): 70-75.
  87. Substrate Stiffness Regulates PDGF-Induced Circular Dorsal Ruffle Formation Through MLCK
    Huyhn, J., F. Bordeleau, C.M. Kraning-Rush, C.A. Reinhart-King
    Cellular and Molecular Bioengineering, 2013, 6(2): 138-147.
  88. A Physical Sciences Network Characterization of Non-Tumorigenic and Metastatic Cells The Physical Sciences–Oncology Network*
    Kraning-Rush, C.M., Reinhart-King, C.A. et al.
    Scientific Reports, 2013, 3: 1449. doi: 10.1038/srep01449.
    (*denotes a group of investigators within the NCI-PSOC network who co-authored this article).
  89. Leading Malignant Cells Initiate Collective Epithelial Cell Invasion in a Three- Dimensional Heterotypic Tumor Spheroid Model
    Carey, S.P., A. Starchenko, A.L. McGregor, C.A. Reinhart-King
    Clinical and Experimental Metastasis, 2013, 30(5): 615-630.
  90. Microfabricated Collagen Tracks Facilitate Single Cell Metastatic Invasion in 3D
    Kraning-Rush, C.M., S.P. Carey, M.C. Lampi, C.A. Reinhart-King
    Integrative Biology, 2013, 5(3): 606-16.
  91. Elucidating Mechanical Transition Effects of Invading Cancer Cells with a Subnucleus-Scaled Microfluidic Serial Dimensional Modulation Device
    Mak, M., C.A. Reinhart-King, D. Erickson
    Lab on a Chip, 2013, 13(3): 340-8.
  92. Tuning 3D Collagen Matrix Stiffness Independently of Collagen Concentration Modulates Endothelial Cell Behavior
    Mason, B.N., A. Starchenko, R.M. Williams, L.J. Bonassar, C.A. Reinhart-King
    Acta Biomaterialia, 2012, 2013, 9(1): 4635-44.
  93. Matrix Mechanics in the Regulation of Angiogenesis
    Califano, J.P. and C.A. Reinhart-King
    Mechanical and Chemical Signaling in Angiogenesis
    , C.A. Reinhart-King (Ed.), 2013, Springer.
  94. Matrix Stiffness: A Regulator of Cellular Behavior and Tissue Formation
    Mason, B.N., J.P. Califano and C.A. Reinhart-King
    Engineering Biomaterials for Regenerative Medicine, S. Bhatia (Ed.), 2012, Springer.
  95. Inducing Apoptosis in Rolling Cancer Cells: A Combined Therapy with Aspirin and Immobilized TRAIL & E-Selectin
    Rana, K., C.A. Reinhart-King, M.R. King
    Molecular Pharmaceutics
    , 2012, 9 (8): 2219–2227.
  96. Controlling matrix stiffness and topography for the study of tumor cell migration
    Kraning-Rush, C.M. and C.A. Reinhart-King
    Cell Adhesion and Migration, 2012, 6(3): 274-279.
  97. Implanted adipose progenitor cells as physicochemical regulators of breast cancer
    Brooks, E.M., B.R. Seo, J.P. Califano, R.C. Andresen Eguiluz, J.S. Lee, C.J. Yoon, D.T. Tims, J.X. Wang, L. Cheng, S. Mohanan, M.R. Buckley, I. Cohen, A.Y. Nikitin, R.M. Williams, D. Gourdon, C.A. Reinhart-King, and C. Fischbach,
    Proceedings of the National Academy of Sciences, 2012, 109(25): 9786-91.
  98. Mechanobiology of Tumor Invasion: where engineering meets oncology
    Carey, S.P, T.M. D’Alfonso, S.J. Shin, C.A. Reinhart-King
    Clinical Reviews in Oncology and Hematology, 2012, 83(2): 170-183.
  99. Quantifying Traction Stresses During Cell Migration
    Kraning -Rush, C.M., S.P. Carey, J.P. Califano and C.A. Reinhart-King,
    Methods in Cell Biology, 2012, 110: 139-178.
  100. Biophysical control of invasive tumor cell behavior by extracellular matrix microarchitecture,
    Carey, S.P., C.M. Kraning-Rush, R. Williams, C.A. Reinhart-King
    , 2012, 33(16): 4157-65.
  101. Cellular Traction Stresses Increase with Increasing Metastatic Potential,
    Kraning-Rush, C.M., J.P. Califano and C.A. Reinhart-King
    PLoS ONE
    , 2012, 7(2): e32572. doi:10.1371/journal.pone.0032572.
  102. Approaches to manipulating the dimensionality and physicochemical properties of common cellular scaffolds
    Bajpai, S., N-Y Kim, C.A. Reinhart-King
    International Journal of Molecular Sciences, 2011, 12(12): 8596-609.
  103. Fabrication of substrates with defined mechanical properties and topographical features for the study of cell migration
    Charest, J., J.P. Califano, S.P. Carey and C.A. Reinhart-King
    Macromolecular Bioscience
    , 2012, 12(1): 12-20.
  104. Single cell-mediated collagen reorganization in 3D matrices,
    Carey S.P., C.M. Kraning-Rush, C.A. Reinhart-King
    Conf Proc IEEE Eng Med Biol Soc., 2011, Aug: 4333-5.
  105. How Matrix Properties Control the Self-Assembly and Maintenance of Tissues
    C.A. Reinhart-King
    Annals of Biomedical Engineering, 2011,39(7): 1849-56.
  106. Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration
    Huynh, J., K. Rana, N. Nozomi, J.M. Peloquin, J.P. Califano, C.M. Montague, C.B. Schaffer, M.R. King, C.A. Reinhart-King
    Science Translational Medicine, 2011, 3(112): 112ra122.
  107. PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation
    Heo, K., H. Lee, P. Nigro, T. Thomas, N. Le, E. Chang, C. McClain, C.A. Reinhart-King, M.R. King, B.C. Berk, K. Fujiwara, C. Woo, J. Abe,
    Journal of Cell Biology, 2011, 193(5): 867-84.
  108. Cancer Cell Migration and Metastasis in the Microenvironment: A Tapered Microchannel Approach for Single Cell Studies
    Mak, M., C.A. Reinhart-King and D. Erickson
    Plos One, 2011, 6(6): e20825.
  109. Indentation Measurements of the Subendothelial Matrix in Bovine Carotid Arteries.
    Peloquin, J.M., J. Huynh, R.M. Williams, C.A. Reinhart-King
    Journal of Biomechanics, 2011, 44, 815-821.
  110. The Role of the Cytoskeleton in Cellular Force Generation in 2D and 3D.
    Kraning-Rush C., S.P. Carey, J.P. Califano, B.N. Smith and C.A. Reinhart-King
    Physical Biology, 2011, 8(1): 015009
  111. Cell-Generated Forces in Tissue Assembly and Function
    Huynh, J., Calfano, J.P., and C.A. Reinhart-King
    Mechanobiology of Cell-Cell & Cell-Matrix Interactions,
    A.J. Wagoner-Johnson and B. Harley (Ed.) Springer, 2011.
  112. Biodegradable Functional Poly(ester amide)s with Pendant Hydroxyl Functional Groups: Synthesis, Characterization, Fabrication and In Vitro Cellular Response.
    Deng M., Wu J., Reinhart-King C.A., Chu C.C.
    Acta Biomaterialia, 2011, 7(4): 1504-15.
  113. Forces During Cell Spreading and Adhesion
    Carey, S, J. Charest, J., and C.A. Reinhart-King
    Studies in Mechanobiology, Tissue Engineering and Biomaterials: Cellular and Biomolecular Mechanics and Mechanobiology

    A. Gefen (Ed.), Springer, 2011.
  114. Synthesis and characterization of functionalized water soluble cationic poly(ester amide)s
    Pang, X., J. Wu, C.A. Reinhart-King, and C.C. Chu
    J. Polym. Sci. Part A: Polymer Chemistry, 2010, 48(17): 3758-3766.
  115. Synthesis, Characterization and Cytotoxicity of Photo-Crosslinked Maleic Chitosan– Polyethylene Glycol Diacrylate Hybrid Hydrogels
    Zhong C., J. Wu, C.A. Reinhart-King and C. C. Chu
    Acta Biomaterialia, 2010, 6(10): 3908-3918. 
  116. Biological performance of biodegradable amino acid-based poly(ester amide)s: Endothelial cell adhesion and inflammation in vitro
    Horwitz, J.A., K.M. Shum, J.C. Bodle, M. Deng, C.C. Chu, and C.A. Reinhart-King
    Journal of Biomedical Materials Research, 2010, 95(2): 371-80.
  117. Control of cell migration using a conducting polymer device
    Gumus, A. J.P Califano, A.M.D. Wan, J. Huynh, C.A. Reinhart-King and G.G. Malliaras
    Soft Matter, 2010, 6: 5138-5142.
  118. Substrate Stiffness and Cell Area Predict Cellular Traction Stresses in Single Cells and Cells in Contact
    Califano, J.P. and C.A. Reinhart-King
    Cellular and Molecular Engineering, 2010, 3(1): 68-75.  

  119. The effects of substrate elasticity on endothelial cell network formation and traction force generation.
    Califano JP, Reinhart-King C.A.
    Conf Proc IEEE Eng Med Biol Soc, 2009, 1: 3343-5. 
  120. Synthesis and Characterization of biodegradable poly(ester amide)s with pendant amine function groups and in vitro cellular response
    Deng, M., Wu, J., Reinhart-King, C.A. and C.C. Chu
    Biomacromolecules, 2009, 10(11): 3037-47.
  121. Exogenous and Endogenous Force Regulation of Endothelial Cells
    Califano, J.P. and C.A. Reinhart-King
    Journal of Biomechanics, 2010, 43(1): 79-86. 
  122. A Balance of Chemistry and Mechanics Regulates Endothelial Network Formation
    Califano, J.P. and C.A. Reinhart-King
    Cell and Molecular Bioengineering, 2008, 1(2-3): p122-132.
    Selected as an Outstanding Paper within the Cellular and Molecular Engineering Track at the 2008 Annual BMES meeting.
  123. Endothelial Cell Adhesion and Migration
    C.A. Reinhart-King
    Methods in Enzymology, 2008, 443: 45-64.

Early Work

  1. Physiologic Stress-Mediated Signaling in the Endothelium
    Reinhart-King, C.A., K. Fujiwara, B.C. Berk
    Methods in Enzymology, 2008, 443: 25-44.
  2. Cell-Cell Mechanical Communication through Compliant Substrates
    Reinhart-King, C.A., M. Dembo, and D.A. Hammer
    Biophysical Journal, 2008, 95(12): 6044-51.
  3. Tensional Homeostasis and the Malignant Phenotype
    Paszek, M.J., N. Zahir, K.R. Johnson, J.N. Lakins, G.I. Rozenberg, A. Gefen
    C.A. Reinhart-King, S.S. Margulies, M. Dembo, D. Boettiger, D.A. Hammer, V.M. Weaver
    Cancer Cell, 2005, 8(3): 241-54. (Cover Article)
  4. The Dynamics and Mechanics of Endothelial Cell Spreading
    Reinhart-King, C.A., M. Dembo, and D.A. Hammer
    Biophysical Journal, 2005, 89(1): 676-89.
  5. Traction Forces Exerted by Adherent Cells
    Reinhart-King, C.A. and D.A. Hammer,
    Advances in Cellular Engineering: Understanding the Biomolecular Interface, 2005.
    M.R. King (Ed.), Academic Press, New York: 3-24.
  6. Dynamic Heterodimer-Functionalized Surfaces for Endothelial Cell Adhesion
    Willcox, P.J., C.A. Reinhart-King, S.J. Lahr, and D.A. Hammer
    Biomaterials, 2005, 26(23): 4757-66.
  7. Endothelial Cell Traction Forces on RGD-Derivatized Polyacrylamide Substrata
    Reinhart-King, C.A., M. Dembo, and D.A. Hammer
    2003, 19(5): 1573-1579.
  8. The Role of Transient ERK2 Signals in Fibronectin- and Insulin-mediated DNA Synthesis
    Asthagiri, A.R., C.A. Reinhart, A.F. Horwitz, and D.A. Lauffenburger
    Journal of Cell Science, 2000, 113(24): 4499-510.
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