Reinhart-King Laboratory

Multidisciplinary approaches to understanding cellular mechanics and cell-biomaterial interactions

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The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria

Libring S, Berestesky ED, Reinhart-King CA.

Clin Exp Metastasis, 2024, PMID: 38489056

Forces exerted and transduced by cancer-associated fibroblasts during cancer progression

Bates ME, Libring S, Reinhart-King CA.

Biol Cell, 2023, PMID: 37224184

Mitochondrial transfer from cancer-associated fibroblasts increases migration in aggressive breast cancer

Goliwas KF, Libring S, Berestesky E, Gholizadeh S, Schwager SC, Frost AR, Gaborski TR, Zhang J, Reinhart-King CA.

J Cell Sci, 2023, PMID: 37358264

Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA

Wang W, Taufalele PV, Millet M, Homsy K, Smart K, Berestesky ED, Schunk CT, Rowe MM, Bordeleau F, Reinhart-King CA.

Cell Rep, 2023, PMID: 37027295

Confinement primes cells for faster migration by polarizing active mitochondria

Mosier JA, Fabiano ED, Ludolph CM, White AE, Reinhart-King CA.

Nanoscale Adv, 2023, PMID: 38125598

Cellular mechanosignaling for sensing and transducing matrix rigidity

Young KM, Reinhart-King CA.

Curr Opin Cell Biol, 2023, PMID: 37473514

Phenotypically sorted highly and weakly migratory triple negative breast cancer cells exhibit migratory and metastatic commensalism

Hapach LA, Wang W, Schwager SC, Pokhriyal D, Fabiano ED, Reinhart-King CA.

Breast Cancer Res, 2023, PMID: 37649089

Matrix stiffness enhances cancer-macrophage interactions and M2-like macrophage accumulation in the breast tumor microenvironment

Taufalele PV, Wang W, Simmons AJ, Southard-Smith AN, Chen B, Greenlee JD, King MR, Lau KS, Hassane DC, Bordeleau F, Reinhart-King CA.

Acta Biomater, 2023, PMID: 35483629

Analysis of Energy-Driven Leader-Follower Hierarchy During Collective Cancer Cell Invasion

Zhang J, Reinhart-King CA.

Methods Mol Biol, 2023, PMID: 36653712

Cancer-associated fibroblasts in early-stage lung adenocarcinoma correlate with tumor aggressiveness

Vasiukov G, Zou Y, Senosain MF, Rahman JSM, Antic S, Young KM, Grogan EL, Kammer MN, Maldonado F, Reinhart-King CA, Massion PP.

Sci Rep, 2023, PMID: 37848457

Matrix stiffness induces epithelial-to-mesenchymal transition via Piezo1-regulated calcium flux in prostate cancer cells

Lopez-Cavestany M, Hahn SB, Hope JM, Reckhorn NT, Greenlee JD, Schwager SC, VanderBurgh JA, Reinhart-King CA, King MR.

iScience, 2023, PMID: 36950111

Tissue density in the progression of breast cancer: Bedside to bench and back again

Fabiano E, Zhang J, Reinhart-King CA.

Curr Opin Biomed Eng, 2022, PMID: 35463199

Link between glucose metabolism and epithelial-to-mesenchymal transition drives triple-negative breast cancer migratory heterogeneity

Schwager SC, Mosier JA, Padmanabhan RS, White A, Xing Q, Hapach LA, Taufalele PV, Ortiz I, Reinhart-King CA.

iScience, 2022, PMID: 36274934

Highly motile cells are metabolically responsive to collagen density

Zanotelli MR, Zhang J, Ortiz I, Wang W, Chada NC, Reinhart-King CA.

Proc Natl Acad Sci U S A, 2022, PMID: 35471912

AGE-breaker ALT711 reverses glycation-mediated cancer cell migration

Rowe MM, Wang W, Taufalele PV, Reinhart-King CA.

Soft Matter, 2022, PMID: 36325938

Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis

Schwager SC, Young KM, Hapach LA, Carlson CM, Mosier JA, McArdle TJ, Wang W, Schunk C, Jayathilake AL, Bates ME, Bordeleau F, Antonyak MA, Cerione RA, Reinhart-King CA.

Elife, 2022, PMID: 36475545

Diabetic hyperglycemia promotes primary tumor progression through glycation-induced tumor extracellular matrix stiffening

Wang W, Hapach LA, Griggs L, Smart K, Wu Y, Taufalele PV, Rowe MM, Young KM, Bates ME, Johnson AC, Ferrell NJ, Pozzi A, Reinhart-King CA.

Sci Adv, 2022, PMID: 36399580

Fluid shear stress enhances T cell activation through Piezo1

Hope JM, Dombroski JA, Pereles RS, Lopez-Cavestany M, Greenlee JD, Schwager SC, Reinhart-King CA, King MR.

BMC Biol, 2022, PMID: 35260156

Lysyl oxidase-like 1 deficiency alters ultrastructural and biomechanical properties of the peripapillary sclera in mice

Wareham LK, Kuchtey J, Wu HJ, Krystofiak E, Wu Y, Reinhart-King CA, Kuchtey RW.

Matrix Biol Plus, 2022, PMID: 36060791

The Nucleus Bypasses Obstacles by Deforming Like a Drop with Surface Tension Mediated by Lamin A/C

Katiyar A, Zhang J, Antani JD, Yu Y, Scott KL, Lele PP, Reinhart-King CA, Sniadecki NJ, Roux KJ, Dickinson RB, Lele TP.

Adv Sci (Weinh), 2022, PMID: 35712768

Phenotypic heterogeneity and cooperation in the metastatic cascade

Young KM, Reinhart-King CA.

Oncoscience, 2022, PMID: 36168407

Cancer cell metabolic plasticity in migration and metastasis

Mosier JA, Schwager SC, Boyajian DA, Reinhart-King CA.

Clin Exp Metastasis, 2021, PMID: 34076787

Phenotypic Heterogeneity and Metastasis of Breast Cancer Cells

Hapach LA, Carey SP, Schwager SC, Taufalele PV, Wang W, Mosier JA, Ortiz-Otero N, McArdle TJ, Goldblatt ZE, Lampi MC, Bordeleau F, Marshall JR, Richardson IM, Li J, King MR, Reinhart-King CA.

Cancer Res, 2021, PMID: 33975882

Mechanoresponsive metabolism in cancer cell migration and metastasis

Zanotelli MR, Zhang J, Reinhart-King CA.

Cell Metab, 2021, PMID: 33915111

Recent advances in understanding the role of metabolic heterogeneities in cell migration

Mosier JA, Wu Y, Reinhart-King CA.

Fac Rev, 2021, PMID: 33659926

Matrix stiffness primes cells for future oxidative stress

Taufalele PV, Reinhart-King CA.

Trends Cancer, 2021, PMID: 34417163

Matrix-driven changes in metabolism support cytoskeletal activity to promote cell migration

Wu Y, Zanotelli MR, Zhang J, Reinhart-King CA.

Biophys J, 2021, PMID: 33705759

Taxanes Sensitize Prostate Cancer Cells to TRAIL-Induced Apoptotic Synergy via Endoplasmic Reticulum Stress

Grayson KA, Hope JM, Wang W, Reinhart-King CA, King MR.

Mol Cancer Ther, 2021, PMID: 33632873

Mechanobiology of microvesicle release, uptake, and microvesicle-mediated activation

Schwager SC, Reinhart-King CA.

Curr Top Membr, 2020, PMID: 33837695

Targeting Tissue Stiffness in Metastasis: Mechanomedicine Improves Cancer Therapy

Zhang J, Reinhart-King CA.

Cancer Cell, 2020, PMID: 32516585

High type I collagen density fails to increase breast cancer stem cell phenotype

Valadão IC, Ralph ACL, Bordeleau F, Dzik LM, Borbely KSC, Geraldo MV, Reinhart-King CA, Freitas VM.

PeerJ, 2020, PMID: 32435546

Cancer associated fibroblasts confer shear resistance to circulating tumor cells during prostate cancer metastatic progression

Ortiz-Otero N, Clinch AB, Hope J, Wang W, Reinhart-King CA, King MR.

Oncotarget, 2020, PMID: 32256977

Tissue transglutaminase 2 regulates tumor cell tensional homeostasis by increasing contractility

Bordeleau F, Wang W, Simmons A, Antonyak MA, Cerione RA, Reinhart-King CA.

J Cell Sci, 2020, PMID: 31822629

A discrete interface in matrix stiffness creates an oscillatory pattern of endothelial monolayer disruption

VanderBurgh JA, Potharazu AV, Schwager SC, Reinhart-King CA.

J Cell Sci, 2020, PMID: 32878941

Stiffness Sensing by Cells

Janmey PA, Fletcher DA, Reinhart-King CA.

Physiol Rev, 2020, PMID: 31751165

Intrastromal Injection of Hyaluronidase Alters the Structural and Biomechanical Properties of the Corneal Stroma

Kim S, Jalilian I, Thomasy SM, Bowman MAW, Raghunathan VK, Song Y, Reinhart-King CA, Murphy CJ.

Transl Vis Sci Technol, 2020, PMID: 32821518

Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making

Zanotelli MR, Rahman-Zaman A, VanderBurgh JA, Taufalele PV, Jain A, Erickson D, Bordeleau F, Reinhart-King CA.

Nat Commun, 2019, PMID: 31519914

Cell-Cell Mechanical Communication in Cancer

Schwager SC, Taufalele PV, Reinhart-King CA.

Cell Mol Bioeng, 2019, PMID: 31565083

Energetic regulation of coordinated leader-follower dynamics during collective invasion of breast cancer cells

Zhang J, Goliwas KF, Wang W, Taufalele PV, Bordeleau F, Reinhart-King CA.

Proc Natl Acad Sci U S A, 2019, PMID: 30923113

Matrix stiffness regulates microvesicle-induced fibroblast activation

Schwager SC, Bordeleau F, Zhang J, Antonyak MA, Cerione RA, Reinhart-King CA.

Am J Physiol Cell Physiol, 2019, PMID: 31017799

Microscale Interrogation of 3D Tissue Mechanics

Zhang J, Chada NC, Reinhart-King CA.

Front Bioeng Biotechnol, 2019, PMID: 31921816

Engineered models to parse apart the metastatic cascade

Hapach LA, Mosier JA, Wang W, Reinhart-King CA.

NPJ Precis Oncol, 2019, PMID: 31453371

Extent of Cell Confinement in Microtracks Affects Speed and Results in Differential Matrix Strains

Mosier JA, Rahman-Zaman A, Zanotelli MR, VanderBurgh JA, Bordeleau F, Hoffman BD, Reinhart-King CA.

Biophys J, 2019, PMID: 31623884

Activation of Piezo1 sensitizes cells to TRAIL-mediated apoptosis through mitochondrial outer membrane permeability

Hope JM, Lopez-Cavestany M, Wang W, Reinhart-King CA, King MR.

Cell Death Dis, 2019, PMID: 31685811

Author Correction: Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making

Zanotelli MR, Rahman-Zaman A, VanderBurgh JA, Taufalele PV, Jain A, Erickson D, Bordeleau F, Reinhart-King CA.

Nat Commun, 2019, PMID: 31797873

Matrix stiffness regulates vascular integrity through focal adhesion kinase activity

Wang W, Lollis EM, Bordeleau F, Reinhart-King CA.

FASEB J, 2019, PMID: 30102569

Fiber alignment drives changes in architectural and mechanical features in collagen matrices

Taufalele PV, VanderBurgh JA, Muñoz A, Zanotelli MR, Reinhart-King CA.

PLoS One, 2019, PMID: 31091287

Cell focal adhesion clustering leads to decreased and homogenized basal strains

Kohn JC, Abdalrahman T, Sack KL, Reinhart-King CA, Franz T.

Int J Numer Method Biomed Eng, 2019, PMID: 31484224

Regulation of ATP utilization during metastatic cell migration by collagen architecture

Zanotelli MR, Goldblatt ZE, Miller JP, Bordeleau F, Li J, VanderBurgh JA, Lampi MC, King MR, Reinhart-King CA.

Mol Biol Cell, 2018, PMID: 29118073

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

Lampi MC, Reinhart-King CA.

Sci Transl Med, 2018, PMID: 29298864

Cell Migration in Microfabricated 3D Collagen Microtracks is Mediated through the Prometastatic Protein Girdin

Rahman-Zaman A, Shan S, Reinhart-King CA.

Cell Mol Bioeng, 2018, PMID: 29403565

Mechanical Forces in Tumor Angiogenesis

Zanotelli MR, Reinhart-King CA.

Adv Exp Med Biol, 2018, PMID: 30368750

The Role of Age-Related Intimal Remodeling and Stiffening in Atherosclerosis

VanderBurgh JA, Reinhart-King CA.

Adv Pharmacol, 2018, PMID: 29310802

Traction Force Microscopy for Noninvasive Imaging of Cell Forces

Mulligan JA, Bordeleau F, Reinhart-King CA, Adie SG.

Adv Exp Med Biol, 2018, PMID: 30368759

High-Fat, High-Sugar Diet-Induced Subendothelial Matrix Stiffening is Mitigated by Exercise

Kohn JC, Azar J, Seta F, Reinhart-King CA.

Cardiovasc Eng Technol, 2018, PMID: 29159794

Determining mechanical features of modulated epithelial monolayers using subnuclear particle tracking

Armiger TJ, Lampi MC, Reinhart-King CA, Dahl KN.

J Cell Sci, 2018, PMID: 29748381

Beneficial Effects of Exercise on Subendothelial Matrix Stiffness are Short-Lived

Kohn JC, Bordeleau F, Miller J, Watkins HC, Modi S, Ma J, Azar J, Putnam D, Reinhart-King CA.

J Biomech Eng, 2018, PMID: 29560498

Eigenstrain as a mechanical set-point of cells

Lin S, Lampi MC, Reinhart-King CA, Tsui G, Wang J, Nelson CA, Gu L.

Biomech Model Mechanobiol, 2018, PMID: 29404724

Endothelial cells on an aged subendothelial matrix display heterogeneous strain profiles in silico

Kohn JC, Abdalrahman T, Sack KL, Reinhart-King CA, Franz T.

Biomech Model Mechanobiol, 2018, PMID: 29802577

Quantitative assessment of cell contractility using polarized light microscopy

Wang W, Miller JP, Pannullo SC, Reinhart-King CA, Bordeleau F.

J Biophotonics, 2018, PMID: 29931742

Clinical doses of radiation reduce collagen matrix stiffness

Miller JP, Borde BH, Bordeleau F, Zanotelli MR, LaValley DJ, Parker DJ, Bonassar LJ, Pannullo SC, Reinhart-King CA.

APL Bioeng, 2018, PMID: 31069314

Substrate stiffness heterogeneities disrupt endothelial barrier integrity in a micropillar model of heterogeneous vascular stiffening

VanderBurgh JA, Hotchkiss H, Potharazu A, Taufalele PV, Reinhart-King CA.

Integr Biol (Camb), 2018, PMID: 30382278

Matrix Stiffness Enhances VEGFR-2 Internalization, Signaling, and Proliferation in Endothelial Cells

LaValley DJ, Zanotelli MR, Bordeleau F, Wang W, Schwager SC, Reinhart-King CA.

Converg Sci Phys Oncol, 2017, PMID: 29531793

Three-dimensional collagen matrix induces a mechanosensitive invasive epithelial phenotype

Carey SP, Martin KE, Reinhart-King CA.

Sci Rep, 2017, PMID: 28186196

Photopatterned Hydrogels to Investigate the Endothelial Cell Response to Matrix Stiffness Heterogeneity

Lampi MC, Guvendiren M, Burdick JA, Reinhart-King CA.

ACS Biomater Sci Eng, 2017, PMID: 33418721

Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy

Mulligan JA, Bordeleau F, Reinhart-King CA, Adie SG.

Biomed Opt Express, 2017, PMID: 28271010

Matrix stiffening promotes a tumor vasculature phenotype

Bordeleau F, Mason BN, Lollis EM, Mazzola M, Zanotelli MR, Somasegar S, Califano JP, Montague C, LaValley DJ, Huynh J, Mencia-Trinchant N, Negrón Abril YL, Hassane DC, Bonassar LJ, Butcher JT, Weiss RS, Reinhart-King CA.

Proc Natl Acad Sci U S A, 2017, PMID: 28034921

The Mechanics of Single Cell and Collective Migration of Tumor Cells

Lintz M, Muñoz A, Reinhart-King CA.

J Biomech Eng, 2017, PMID: 27814431

Tuning cell migration: contractility as an integrator of intracellular signals from multiple cues

Bordeleau F, Reinhart-King CA.

F1000Res, 2016, PMID: 27508074

Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation

Desrochers LM, Bordeleau F, Reinhart-King CA, Cerione RA, Antonyak MA.

Nat Commun, 2016, PMID: 27302045

Local extracellular matrix alignment directs cellular protrusion dynamics and migration through Rac1 and FAK

Carey SP, Goldblatt ZE, Martin KE, Romero B, Williams RM, Reinhart-King CA.

Integr Biol (Camb), 2016, PMID: 27384462

3D Bioprinting of Spatially Heterogeneous Collagen Constructs for Cartilage Tissue Engineering

Rhee S, Puetzer JL, Mason BN, Reinhart-King CA, Bonassar LJ.

ACS Biomater Sci Eng, 2016, PMID: 33440478

Improving fascin inhibitors to block tumor cell migration and metastasis

Han S, Huang J, Liu B, Xing B, Bordeleau F, Reinhart-King CA, Li W, Zhang JJ, Huang XY.

Mol Oncol, 2016, PMID: 27071719

Mechanical heterogeneities in the subendothelial matrix develop with age and decrease with exercise

Kohn JC, Chen A, Cheng S, Kowal DR, King MR, Reinhart-King CA.

J Biomech, 2016, PMID: 27020750

Vinculin Regulates Directionality and Cell Polarity in 2D, 3D Matrix and 3D Microtrack Migration

Rahman A, Carey SP, Kraning-Rush CM, Goldblatt ZE, Bordeleau F, Lampi MC, Lin DY, García AJ, Reinhart-King CA.

Mol Biol Cell, 2016, PMID: 26960796

Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption

Lampi MC, Faber CJ, Huynh J, Bordeleau F, Zanotelli MR, Reinhart-King CA.

PLoS One, 2016, PMID: 26761203

Self-Assembled Cationic Biodegradable Nanoparticles from pH-Responsive Amino-Acid-Based Poly(Ester Urea Urethane)s and Their Application As a Drug Delivery Vehicle

He M, Potuck A, Kohn JC, Fung K, Reinhart-King CA, Chu CC.

Biomacromolecules, 2016, PMID: 26650653

Microvesicles released from tumor cells disrupt epithelial cell morphology and contractility

Bordeleau F, Chan B, Antonyak MA, Lampi MC, Cerione RA, Reinhart-King CA.

J Biomech, 2016, PMID: 26477404

Comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks

Carey SP, Rahman A, Kraning-Rush CM, Romero B, Somasegar S, Torre OM, Williams RM, Reinhart-King CA.

Am J Physiol Cell Physiol, 2015, PMID: 25500742

Age-related vascular stiffening: causes and consequences

Kohn JC, Lampi MC, Reinhart-King CA.

Front Genet, 2015, PMID: 25926844

Probing the biophysical properties of primary breast tumor-derived fibroblasts

Alcoser TA, Bordeleau F, Carey SP, Lampi MC, Kowal DR, Somasegar S, Varma S, Shin SJ, Reinhart-King CA.

Cell Mol Bioeng, 2015, PMID: 25866589

Manipulation of in vitro collagen matrix architecture for scaffolds of improved physiological relevance

Hapach LA, VanderBurgh JA, Miller JP, Reinhart-King CA.

Phys Biol, 2015, PMID: 26689380

The 2015 Young Innovators of Cellular and Molecular Bioengineering

Reinhart-King CA, Schmidt CE, Peppas NA.

Cell Mol Bioeng, 2015, PMID: 26366229

Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors

Bordeleau F, Califano JP, Negrón Abril YL, Mason BN, LaValley DJ, Shin SJ, Weiss RS, Reinhart-King CA.

Proc Natl Acad Sci U S A, 2015, PMID: 26106154

Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization

Huang FK, Han S, Xing B, Huang J, Liu B, Bordeleau F, Reinhart-King CA, Zhang JJ, Huang XY.

Nat Commun, 2015, PMID: 26081695

Biophysical induction of vascular smooth muscle cell podosomes

Kim NY, Kohn JC, Huynh J, Carey SP, Mason BN, Vouyouka AG, Reinhart-King CA.

PLoS One, 2015, PMID: 25785437

Cooperative effects of matrix stiffness and fluid shear stress on endothelial cell behavior

Kohn JC, Zhou DW, Bordeleau F, Zhou AL, Mason BN, Mitchell MJ, King MR, Reinhart-King CA.

Biophys J, 2015, PMID: 25650915

Physical biology in cancer. 5. The rocky road of metastasis: the role of cytoskeletal mechanics in cell migratory response to 3D matrix topography

Bordeleau F, Alcoser TA, Reinhart-King CA.

Am J Physiol Cell Physiol, 2014, PMID: 24196535

The Young Innovators of Cellular and Molecular Bioengineering

Reinhart-King CA, Mooney DJ, Schaffer DV.

Cell Mol Bioeng, 2014, PMID: 25309632

Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro

van Oers RF, Rens EG, LaValley DJ, Reinhart-King CA, Merks RM.

PLoS Comput Biol, 2014, PMID: 25121971

A microfluidic device to select for cells based on chemotactic phenotype

Bajpai S, Mitchell MJ, King MR, Reinhart-King CA.

Technology (Singap World Sci), 2014, PMID: 24999488

Leading malignant cells initiate collective epithelial cell invasion in a three-dimensional heterotypic tumor spheroid model

Carey SP, Starchenko A, McGregor AL, Reinhart-King CA.

Clin Exp Metastasis, 2013, PMID: 23328900

Topographical guidance of 3D tumor cell migration at an interface of collagen densities

Bordeleau F, Tang LN, Reinhart-King CA.

Phys Biol, 2013, PMID: 24304905

Microfabricated collagen tracks facilitate single cell metastatic invasion in 3D

Kraning-Rush CM, Carey SP, Lampi MC, Reinhart-King CA.

Integr Biol (Camb), 2013, PMID: 23388698

Controlling the mechanical properties of three-dimensional matrices via non-enzymatic collagen glycation

Mason BN, Reinhart-King CA.

Organogenesis, 2013, PMID: 23811696

Substrate Stiffness Regulates PDGF-Induced Circular Dorsal Ruffle Formation Through MLCK

Huynh J, Bordeleau F, Kraning-Rush CM, Reinhart-King CA.

Cell Mol Bioeng, 2013, PMID: 24348877

Arterial stiffening precedes systolic hypertension in diet-induced obesity

Weisbrod RM, Shiang T, Al Sayah L, Fry JL, Bajpai S, Reinhart-King CA, Lob HE, Santhanam L, Mitchell G, Cohen RA, Seta F.

Hypertension, 2013, PMID: 24060894

A physical sciences network characterization of non-tumorigenic and metastatic cells

Physical Sciences - Oncology Centers Network; Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH.

Sci Rep, 2013, PMID: 23618955

Elucidating mechanical transition effects of invading cancer cells with a subnucleus-scaled microfluidic serial dimensional modulation device

Mak M, Reinhart-King CA, Erickson D.

Lab Chip, 2013, PMID: 23212313

Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior

Mason BN, Starchenko A, Williams RM, Bonassar LJ, Reinhart-King CA.

Acta Biomater, 2013, PMID: 22902816

Implanted adipose progenitor cells as physicochemical regulators of breast cancer

Chandler EM, Seo BR, Califano JP, Andresen Eguiluz RC, Lee JS, Yoon CJ, Tims DT, Wang JX, Cheng L, Mohanan S, Buckley MR, Cohen I, Nikitin AY, Williams RM, Gourdon D, Reinhart-King CA, Fischbach C.

Proc Natl Acad Sci U S A, 2012, PMID: 22665775

Mechanobiology of tumor invasion: engineering meets oncology

Carey SP, D'Alfonso TM, Shin SJ, Reinhart-King CA.

Crit Rev Oncol Hematol, 2012, PMID: 22178415

Controlling matrix stiffness and topography for the study of tumor cell migration

Kraning-Rush CM, Reinhart-King CA.

Cell Adh Migr, 2012, PMID: 22863740

Quantifying traction stresses in adherent cells

Kraning-Rush CM, Carey SP, Califano JP, Reinhart-King CA.

Methods Cell Biol, 2012, PMID: 22482948

Cellular traction stresses increase with increasing metastatic potential

Kraning-Rush CM, Califano JP, Reinhart-King CA.

PLoS One, 2012, PMID: 22389710

Inducing apoptosis in rolling cancer cells: a combined therapy with aspirin and immobilized TRAIL and E-selectin

Rana K, Reinhart-King CA, King MR.

Mol Pharm, 2012, PMID: 22724630

Biophysical control of invasive tumor cell behavior by extracellular matrix microarchitecture

Carey SP, Kraning-Rush CM, Williams RM, Reinhart-King CA.

Biomaterials, 2012, PMID: 22405848

Fabrication of substrates with defined mechanical properties and topographical features for the study of cell migration

Charest JM, Califano JP, Carey SP, Reinhart-King CA.

Macromol Biosci, 2012, PMID: 22021131

Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration

Huynh J, Nishimura N, Rana K, Peloquin JM, Califano JP, Montague CR, King MR, Schaffer CB, Reinhart-King CA.

Sci Transl Med, 2011, PMID: 22158860

The role of the cytoskeleton in cellular force generation in 2D and 3D environments

Kraning-Rush CM, Carey SP, Califano JP, Smith BN, Reinhart-King CA.

Phys Biol, 2011, PMID: 21301071

Approaches to manipulating the dimensionality and physicochemical properties of common cellular scaffolds

Bajpai S, Kim NY, Reinhart-King CA.

Int J Mol Sci, 2011, PMID: 22272094

Single cell-mediated collagen reorganization in 3D matrices

Carey SP, Kraning-Rush CM, Reinhart-King CA.

Annu Int Conf IEEE Eng Med Biol Soc, 2011, PMID: 22255298

Microfabricated physical spatial gradients for investigating cell migration and invasion dynamics

Mak M, Reinhart-King CA, Erickson D.

PLoS One, 2011, PMID: 21695222

PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation

Heo KS, Lee H, Nigro P, Thomas T, Le NT, Chang E, McClain C, Reinhart-King CA, King MR, Berk BC, Fujiwara K, Woo CH, Abe J.

J Cell Biol, 2011, PMID: 21624955

How matrix properties control the self-assembly and maintenance of tissues

Reinhart-King CA.

Ann Biomed Eng, 2011, PMID: 21491153

Indentation measurements of the subendothelial matrix in bovine carotid arteries

Peloquin J, Huynh J, Williams RM, Reinhart-King CA.

J Biomech, 2011, PMID: 21288524

Biodegradable functional poly(ester amide)s with pendant hydroxyl functional groups: synthesis, characterization, fabrication and in vitro cellular response

Deng M, Wu J, Reinhart-King CA, Chu CC.

Acta Biomater, 2011, PMID: 21187171

Biological performance of biodegradable amino acid-based poly(ester amide)s: Endothelial cell adhesion and inflammation in vitro

Horwitz JA, Shum KM, Bodle JC, Deng M, Chu CC, Reinhart-King CA.

J Biomed Mater Res A, 2010, PMID: 20629024

Substrate Stiffness and Cell Area Predict Cellular Traction Stresses in Single Cells and Cells in Contact

Califano JP, Reinhart-King CA.

Cell Mol Bioeng, 2010, PMID: 21116436

Synthesis, characterization and cytotoxicity of photo-crosslinked maleic chitosan-polyethylene glycol diacrylate hybrid hydrogels

Zhong C, Wu J, Reinhart-King CA, Chu CC.

Acta Biomater, 2010, PMID: 20416406

Exogenous and endogenous force regulation of endothelial cell behavior

Califano JP, Reinhart-King CA.

J Biomech, 2010, PMID: 19815215

The effects of substrate elasticity on endothelial cell network formation and traction force generation

Califano JP, Reinhart-King CA.

Annu Int Conf IEEE Eng Med Biol Soc, 2009, PMID: 19964074

Synthesis and characterization of biodegradable poly(ester amide)s with pendant amine functional groups and in vitro cellular response

Deng M, Wu J, Reinhart-King CA, Chu CC.

Biomacromolecules, 2009, PMID: 19810736

Endothelial cell adhesion and migration

Reinhart-King CA.

Methods Enzymol, 2008, PMID: 18772010

Physiologic stress-mediated signaling in the endothelium

Reinhart-King CA, Fujiwara K, Berk BC.

Methods Enzymol, 2008, PMID: 18772009

Cell-cell mechanical communication through compliant substrates

Reinhart-King CA, Dembo M, Hammer DA.

Biophys J, 2008, PMID: 18775964

Tensional homeostasis and the malignant phenotype

Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM.

Cancer Cell, 2005, PMID: 16169468

The dynamics and mechanics of endothelial cell spreading

Reinhart-King CA, Dembo M, Hammer DA.

Biophys J, 2005, PMID: 15849250

Dynamic heterodimer-functionalized surfaces for endothelial cell adhesion

Willcox PJ, Reinhart-King CA, Lahr SJ, DeGrado WF, Hammer DA.

Biomaterials, 2005, PMID: 15763255