Reinhart-King Laboratory
Multidisciplinary approaches to understanding cellular mechanics and cell-biomaterial interactions
Publications
The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria
Libring S, Berestesky ED, Reinhart-King CA.
Clin Exp Metastasis, 2024, PMID: 38489056
Forces exerted and transduced by cancer-associated fibroblasts during cancer progression
Bates ME, Libring S, Reinhart-King CA.
Biol Cell, 2023, PMID: 37224184
Mitochondrial transfer from cancer-associated fibroblasts increases migration in aggressive breast cancer
Goliwas KF, Libring S, Berestesky E, Gholizadeh S, Schwager SC, Frost AR, Gaborski TR, Zhang J, Reinhart-King CA.
J Cell Sci, 2023, PMID: 37358264
Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA
Wang W, Taufalele PV, Millet M, Homsy K, Smart K, Berestesky ED, Schunk CT, Rowe MM, Bordeleau F, Reinhart-King CA.
Cell Rep, 2023, PMID: 37027295
Confinement primes cells for faster migration by polarizing active mitochondria
Mosier JA, Fabiano ED, Ludolph CM, White AE, Reinhart-King CA.
Nanoscale Adv, 2023, PMID: 38125598
Cellular mechanosignaling for sensing and transducing matrix rigidity
Young KM, Reinhart-King CA.
Curr Opin Cell Biol, 2023, PMID: 37473514
Phenotypically sorted highly and weakly migratory triple negative breast cancer cells exhibit migratory and metastatic commensalism
Hapach LA, Wang W, Schwager SC, Pokhriyal D, Fabiano ED, Reinhart-King CA.
Breast Cancer Res, 2023, PMID: 37649089
Matrix stiffness enhances cancer-macrophage interactions and M2-like macrophage accumulation in the breast tumor microenvironment
Taufalele PV, Wang W, Simmons AJ, Southard-Smith AN, Chen B, Greenlee JD, King MR, Lau KS, Hassane DC, Bordeleau F, Reinhart-King CA.
Acta Biomater, 2023, PMID: 35483629
Analysis of Energy-Driven Leader-Follower Hierarchy During Collective Cancer Cell Invasion
Zhang J, Reinhart-King CA.
Methods Mol Biol, 2023, PMID: 36653712
Cancer-associated fibroblasts in early-stage lung adenocarcinoma correlate with tumor aggressiveness
Vasiukov G, Zou Y, Senosain MF, Rahman JSM, Antic S, Young KM, Grogan EL, Kammer MN, Maldonado F, Reinhart-King CA, Massion PP.
Sci Rep, 2023, PMID: 37848457
Matrix stiffness induces epithelial-to-mesenchymal transition via Piezo1-regulated calcium flux in prostate cancer cells
Lopez-Cavestany M, Hahn SB, Hope JM, Reckhorn NT, Greenlee JD, Schwager SC, VanderBurgh JA, Reinhart-King CA, King MR.
iScience, 2023, PMID: 36950111
Tissue density in the progression of breast cancer: Bedside to bench and back again
Fabiano E, Zhang J, Reinhart-King CA.
Curr Opin Biomed Eng, 2022, PMID: 35463199
Link between glucose metabolism and epithelial-to-mesenchymal transition drives triple-negative breast cancer migratory heterogeneity
Schwager SC, Mosier JA, Padmanabhan RS, White A, Xing Q, Hapach LA, Taufalele PV, Ortiz I, Reinhart-King CA.
iScience, 2022, PMID: 36274934
Highly motile cells are metabolically responsive to collagen density
Zanotelli MR, Zhang J, Ortiz I, Wang W, Chada NC, Reinhart-King CA.
Proc Natl Acad Sci U S A, 2022, PMID: 35471912
AGE-breaker ALT711 reverses glycation-mediated cancer cell migration
Rowe MM, Wang W, Taufalele PV, Reinhart-King CA.
Soft Matter, 2022, PMID: 36325938
Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis
Schwager SC, Young KM, Hapach LA, Carlson CM, Mosier JA, McArdle TJ, Wang W, Schunk C, Jayathilake AL, Bates ME, Bordeleau F, Antonyak MA, Cerione RA, Reinhart-King CA.
Elife, 2022, PMID: 36475545
Diabetic hyperglycemia promotes primary tumor progression through glycation-induced tumor extracellular matrix stiffening
Wang W, Hapach LA, Griggs L, Smart K, Wu Y, Taufalele PV, Rowe MM, Young KM, Bates ME, Johnson AC, Ferrell NJ, Pozzi A, Reinhart-King CA.
Sci Adv, 2022, PMID: 36399580
Fluid shear stress enhances T cell activation through Piezo1
Hope JM, Dombroski JA, Pereles RS, Lopez-Cavestany M, Greenlee JD, Schwager SC, Reinhart-King CA, King MR.
BMC Biol, 2022, PMID: 35260156
Lysyl oxidase-like 1 deficiency alters ultrastructural and biomechanical properties of the peripapillary sclera in mice
Wareham LK, Kuchtey J, Wu HJ, Krystofiak E, Wu Y, Reinhart-King CA, Kuchtey RW.
Matrix Biol Plus, 2022, PMID: 36060791
The Nucleus Bypasses Obstacles by Deforming Like a Drop with Surface Tension Mediated by Lamin A/C
Katiyar A, Zhang J, Antani JD, Yu Y, Scott KL, Lele PP, Reinhart-King CA, Sniadecki NJ, Roux KJ, Dickinson RB, Lele TP.
Adv Sci (Weinh), 2022, PMID: 35712768
Phenotypic heterogeneity and cooperation in the metastatic cascade
Young KM, Reinhart-King CA.
Oncoscience, 2022, PMID: 36168407
Cancer cell metabolic plasticity in migration and metastasis
Mosier JA, Schwager SC, Boyajian DA, Reinhart-King CA.
Clin Exp Metastasis, 2021, PMID: 34076787
Phenotypic Heterogeneity and Metastasis of Breast Cancer Cells
Hapach LA, Carey SP, Schwager SC, Taufalele PV, Wang W, Mosier JA, Ortiz-Otero N, McArdle TJ, Goldblatt ZE, Lampi MC, Bordeleau F, Marshall JR, Richardson IM, Li J, King MR, Reinhart-King CA.
Cancer Res, 2021, PMID: 33975882
Mechanoresponsive metabolism in cancer cell migration and metastasis
Zanotelli MR, Zhang J, Reinhart-King CA.
Cell Metab, 2021, PMID: 33915111
Recent advances in understanding the role of metabolic heterogeneities in cell migration
Mosier JA, Wu Y, Reinhart-King CA.
Fac Rev, 2021, PMID: 33659926
Matrix stiffness primes cells for future oxidative stress
Taufalele PV, Reinhart-King CA.
Trends Cancer, 2021, PMID: 34417163
Matrix-driven changes in metabolism support cytoskeletal activity to promote cell migration
Wu Y, Zanotelli MR, Zhang J, Reinhart-King CA.
Biophys J, 2021, PMID: 33705759
Taxanes Sensitize Prostate Cancer Cells to TRAIL-Induced Apoptotic Synergy via Endoplasmic Reticulum Stress
Grayson KA, Hope JM, Wang W, Reinhart-King CA, King MR.
Mol Cancer Ther, 2021, PMID: 33632873
Mechanobiology of microvesicle release, uptake, and microvesicle-mediated activation
Schwager SC, Reinhart-King CA.
Curr Top Membr, 2020, PMID: 33837695
Targeting Tissue Stiffness in Metastasis: Mechanomedicine Improves Cancer Therapy
Zhang J, Reinhart-King CA.
Cancer Cell, 2020, PMID: 32516585
High type I collagen density fails to increase breast cancer stem cell phenotype
Valadão IC, Ralph ACL, Bordeleau F, Dzik LM, Borbely KSC, Geraldo MV, Reinhart-King CA, Freitas VM.
PeerJ, 2020, PMID: 32435546
Cancer associated fibroblasts confer shear resistance to circulating tumor cells during prostate cancer metastatic progression
Ortiz-Otero N, Clinch AB, Hope J, Wang W, Reinhart-King CA, King MR.
Oncotarget, 2020, PMID: 32256977
Tissue transglutaminase 2 regulates tumor cell tensional homeostasis by increasing contractility
Bordeleau F, Wang W, Simmons A, Antonyak MA, Cerione RA, Reinhart-King CA.
J Cell Sci, 2020, PMID: 31822629
A discrete interface in matrix stiffness creates an oscillatory pattern of endothelial monolayer disruption
VanderBurgh JA, Potharazu AV, Schwager SC, Reinhart-King CA.
J Cell Sci, 2020, PMID: 32878941
Stiffness Sensing by Cells
Janmey PA, Fletcher DA, Reinhart-King CA.
Physiol Rev, 2020, PMID: 31751165
Intrastromal Injection of Hyaluronidase Alters the Structural and Biomechanical Properties of the Corneal Stroma
Kim S, Jalilian I, Thomasy SM, Bowman MAW, Raghunathan VK, Song Y, Reinhart-King CA, Murphy CJ.
Transl Vis Sci Technol, 2020, PMID: 32821518
Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making
Zanotelli MR, Rahman-Zaman A, VanderBurgh JA, Taufalele PV, Jain A, Erickson D, Bordeleau F, Reinhart-King CA.
Nat Commun, 2019, PMID: 31519914
Cell-Cell Mechanical Communication in Cancer
Schwager SC, Taufalele PV, Reinhart-King CA.
Cell Mol Bioeng, 2019, PMID: 31565083
Energetic regulation of coordinated leader-follower dynamics during collective invasion of breast cancer cells
Zhang J, Goliwas KF, Wang W, Taufalele PV, Bordeleau F, Reinhart-King CA.
Proc Natl Acad Sci U S A, 2019, PMID: 30923113
Matrix stiffness regulates microvesicle-induced fibroblast activation
Schwager SC, Bordeleau F, Zhang J, Antonyak MA, Cerione RA, Reinhart-King CA.
Am J Physiol Cell Physiol, 2019, PMID: 31017799
Microscale Interrogation of 3D Tissue Mechanics
Zhang J, Chada NC, Reinhart-King CA.
Front Bioeng Biotechnol, 2019, PMID: 31921816
Engineered models to parse apart the metastatic cascade
Hapach LA, Mosier JA, Wang W, Reinhart-King CA.
NPJ Precis Oncol, 2019, PMID: 31453371
Extent of Cell Confinement in Microtracks Affects Speed and Results in Differential Matrix Strains
Mosier JA, Rahman-Zaman A, Zanotelli MR, VanderBurgh JA, Bordeleau F, Hoffman BD, Reinhart-King CA.
Biophys J, 2019, PMID: 31623884
Activation of Piezo1 sensitizes cells to TRAIL-mediated apoptosis through mitochondrial outer membrane permeability
Hope JM, Lopez-Cavestany M, Wang W, Reinhart-King CA, King MR.
Cell Death Dis, 2019, PMID: 31685811
Author Correction: Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making
Zanotelli MR, Rahman-Zaman A, VanderBurgh JA, Taufalele PV, Jain A, Erickson D, Bordeleau F, Reinhart-King CA.
Nat Commun, 2019, PMID: 31797873
Matrix stiffness regulates vascular integrity through focal adhesion kinase activity
Wang W, Lollis EM, Bordeleau F, Reinhart-King CA.
FASEB J, 2019, PMID: 30102569
Fiber alignment drives changes in architectural and mechanical features in collagen matrices
Taufalele PV, VanderBurgh JA, Muñoz A, Zanotelli MR, Reinhart-King CA.
PLoS One, 2019, PMID: 31091287
Cell focal adhesion clustering leads to decreased and homogenized basal strains
Kohn JC, Abdalrahman T, Sack KL, Reinhart-King CA, Franz T.
Int J Numer Method Biomed Eng, 2019, PMID: 31484224
Regulation of ATP utilization during metastatic cell migration by collagen architecture
Zanotelli MR, Goldblatt ZE, Miller JP, Bordeleau F, Li J, VanderBurgh JA, Lampi MC, King MR, Reinhart-King CA.
Mol Biol Cell, 2018, PMID: 29118073
Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials
Lampi MC, Reinhart-King CA.
Sci Transl Med, 2018, PMID: 29298864
Cell Migration in Microfabricated 3D Collagen Microtracks is Mediated through the Prometastatic Protein Girdin
Rahman-Zaman A, Shan S, Reinhart-King CA.
Cell Mol Bioeng, 2018, PMID: 29403565
Mechanical Forces in Tumor Angiogenesis
Zanotelli MR, Reinhart-King CA.
Adv Exp Med Biol, 2018, PMID: 30368750
The Role of Age-Related Intimal Remodeling and Stiffening in Atherosclerosis
VanderBurgh JA, Reinhart-King CA.
Adv Pharmacol, 2018, PMID: 29310802
Traction Force Microscopy for Noninvasive Imaging of Cell Forces
Mulligan JA, Bordeleau F, Reinhart-King CA, Adie SG.
Adv Exp Med Biol, 2018, PMID: 30368759
High-Fat, High-Sugar Diet-Induced Subendothelial Matrix Stiffening is Mitigated by Exercise
Kohn JC, Azar J, Seta F, Reinhart-King CA.
Cardiovasc Eng Technol, 2018, PMID: 29159794
Determining mechanical features of modulated epithelial monolayers using subnuclear particle tracking
Armiger TJ, Lampi MC, Reinhart-King CA, Dahl KN.
J Cell Sci, 2018, PMID: 29748381
Beneficial Effects of Exercise on Subendothelial Matrix Stiffness are Short-Lived
Kohn JC, Bordeleau F, Miller J, Watkins HC, Modi S, Ma J, Azar J, Putnam D, Reinhart-King CA.
J Biomech Eng, 2018, PMID: 29560498
Eigenstrain as a mechanical set-point of cells
Lin S, Lampi MC, Reinhart-King CA, Tsui G, Wang J, Nelson CA, Gu L.
Biomech Model Mechanobiol, 2018, PMID: 29404724
Endothelial cells on an aged subendothelial matrix display heterogeneous strain profiles in silico
Kohn JC, Abdalrahman T, Sack KL, Reinhart-King CA, Franz T.
Biomech Model Mechanobiol, 2018, PMID: 29802577
Quantitative assessment of cell contractility using polarized light microscopy
Wang W, Miller JP, Pannullo SC, Reinhart-King CA, Bordeleau F.
J Biophotonics, 2018, PMID: 29931742
Clinical doses of radiation reduce collagen matrix stiffness
Miller JP, Borde BH, Bordeleau F, Zanotelli MR, LaValley DJ, Parker DJ, Bonassar LJ, Pannullo SC, Reinhart-King CA.
APL Bioeng, 2018, PMID: 31069314
Substrate stiffness heterogeneities disrupt endothelial barrier integrity in a micropillar model of heterogeneous vascular stiffening
VanderBurgh JA, Hotchkiss H, Potharazu A, Taufalele PV, Reinhart-King CA.
Integr Biol (Camb), 2018, PMID: 30382278
Matrix Stiffness Enhances VEGFR-2 Internalization, Signaling, and Proliferation in Endothelial Cells
LaValley DJ, Zanotelli MR, Bordeleau F, Wang W, Schwager SC, Reinhart-King CA.
Converg Sci Phys Oncol, 2017, PMID: 29531793
Three-dimensional collagen matrix induces a mechanosensitive invasive epithelial phenotype
Carey SP, Martin KE, Reinhart-King CA.
Sci Rep, 2017, PMID: 28186196
Photopatterned Hydrogels to Investigate the Endothelial Cell Response to Matrix Stiffness Heterogeneity
Lampi MC, Guvendiren M, Burdick JA, Reinhart-King CA.
ACS Biomater Sci Eng, 2017, PMID: 33418721
Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy
Mulligan JA, Bordeleau F, Reinhart-King CA, Adie SG.
Biomed Opt Express, 2017, PMID: 28271010
Matrix stiffening promotes a tumor vasculature phenotype
Bordeleau F, Mason BN, Lollis EM, Mazzola M, Zanotelli MR, Somasegar S, Califano JP, Montague C, LaValley DJ, Huynh J, Mencia-Trinchant N, Negrón Abril YL, Hassane DC, Bonassar LJ, Butcher JT, Weiss RS, Reinhart-King CA.
Proc Natl Acad Sci U S A, 2017, PMID: 28034921
The Mechanics of Single Cell and Collective Migration of Tumor Cells
Lintz M, Muñoz A, Reinhart-King CA.
J Biomech Eng, 2017, PMID: 27814431
Tuning cell migration: contractility as an integrator of intracellular signals from multiple cues
Bordeleau F, Reinhart-King CA.
F1000Res, 2016, PMID: 27508074
Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation
Desrochers LM, Bordeleau F, Reinhart-King CA, Cerione RA, Antonyak MA.
Nat Commun, 2016, PMID: 27302045
Local extracellular matrix alignment directs cellular protrusion dynamics and migration through Rac1 and FAK
Carey SP, Goldblatt ZE, Martin KE, Romero B, Williams RM, Reinhart-King CA.
Integr Biol (Camb), 2016, PMID: 27384462
3D Bioprinting of Spatially Heterogeneous Collagen Constructs for Cartilage Tissue Engineering
Rhee S, Puetzer JL, Mason BN, Reinhart-King CA, Bonassar LJ.
ACS Biomater Sci Eng, 2016, PMID: 33440478
Improving fascin inhibitors to block tumor cell migration and metastasis
Han S, Huang J, Liu B, Xing B, Bordeleau F, Reinhart-King CA, Li W, Zhang JJ, Huang XY.
Mol Oncol, 2016, PMID: 27071719
Mechanical heterogeneities in the subendothelial matrix develop with age and decrease with exercise
Kohn JC, Chen A, Cheng S, Kowal DR, King MR, Reinhart-King CA.
J Biomech, 2016, PMID: 27020750
Vinculin Regulates Directionality and Cell Polarity in 2D, 3D Matrix and 3D Microtrack Migration
Rahman A, Carey SP, Kraning-Rush CM, Goldblatt ZE, Bordeleau F, Lampi MC, Lin DY, García AJ, Reinhart-King CA.
Mol Biol Cell, 2016, PMID: 26960796
Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption
Lampi MC, Faber CJ, Huynh J, Bordeleau F, Zanotelli MR, Reinhart-King CA.
PLoS One, 2016, PMID: 26761203
Self-Assembled Cationic Biodegradable Nanoparticles from pH-Responsive Amino-Acid-Based Poly(Ester Urea Urethane)s and Their Application As a Drug Delivery Vehicle
He M, Potuck A, Kohn JC, Fung K, Reinhart-King CA, Chu CC.
Biomacromolecules, 2016, PMID: 26650653
Microvesicles released from tumor cells disrupt epithelial cell morphology and contractility
Bordeleau F, Chan B, Antonyak MA, Lampi MC, Cerione RA, Reinhart-King CA.
J Biomech, 2016, PMID: 26477404
Comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks
Carey SP, Rahman A, Kraning-Rush CM, Romero B, Somasegar S, Torre OM, Williams RM, Reinhart-King CA.
Am J Physiol Cell Physiol, 2015, PMID: 25500742
Age-related vascular stiffening: causes and consequences
Kohn JC, Lampi MC, Reinhart-King CA.
Front Genet, 2015, PMID: 25926844
Probing the biophysical properties of primary breast tumor-derived fibroblasts
Alcoser TA, Bordeleau F, Carey SP, Lampi MC, Kowal DR, Somasegar S, Varma S, Shin SJ, Reinhart-King CA.
Cell Mol Bioeng, 2015, PMID: 25866589
Manipulation of in vitro collagen matrix architecture for scaffolds of improved physiological relevance
Hapach LA, VanderBurgh JA, Miller JP, Reinhart-King CA.
Phys Biol, 2015, PMID: 26689380
The 2015 Young Innovators of Cellular and Molecular Bioengineering
Reinhart-King CA, Schmidt CE, Peppas NA.
Cell Mol Bioeng, 2015, PMID: 26366229
Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors
Bordeleau F, Califano JP, Negrón Abril YL, Mason BN, LaValley DJ, Shin SJ, Weiss RS, Reinhart-King CA.
Proc Natl Acad Sci U S A, 2015, PMID: 26106154
Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization
Huang FK, Han S, Xing B, Huang J, Liu B, Bordeleau F, Reinhart-King CA, Zhang JJ, Huang XY.
Nat Commun, 2015, PMID: 26081695
Biophysical induction of vascular smooth muscle cell podosomes
Kim NY, Kohn JC, Huynh J, Carey SP, Mason BN, Vouyouka AG, Reinhart-King CA.
PLoS One, 2015, PMID: 25785437
Cooperative effects of matrix stiffness and fluid shear stress on endothelial cell behavior
Kohn JC, Zhou DW, Bordeleau F, Zhou AL, Mason BN, Mitchell MJ, King MR, Reinhart-King CA.
Biophys J, 2015, PMID: 25650915
Physical biology in cancer. 5. The rocky road of metastasis: the role of cytoskeletal mechanics in cell migratory response to 3D matrix topography
Bordeleau F, Alcoser TA, Reinhart-King CA.
Am J Physiol Cell Physiol, 2014, PMID: 24196535
The Young Innovators of Cellular and Molecular Bioengineering
Reinhart-King CA, Mooney DJ, Schaffer DV.
Cell Mol Bioeng, 2014, PMID: 25309632
Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro
van Oers RF, Rens EG, LaValley DJ, Reinhart-King CA, Merks RM.
PLoS Comput Biol, 2014, PMID: 25121971
A microfluidic device to select for cells based on chemotactic phenotype
Bajpai S, Mitchell MJ, King MR, Reinhart-King CA.
Technology (Singap World Sci), 2014, PMID: 24999488
Leading malignant cells initiate collective epithelial cell invasion in a three-dimensional heterotypic tumor spheroid model
Carey SP, Starchenko A, McGregor AL, Reinhart-King CA.
Clin Exp Metastasis, 2013, PMID: 23328900
Topographical guidance of 3D tumor cell migration at an interface of collagen densities
Bordeleau F, Tang LN, Reinhart-King CA.
Phys Biol, 2013, PMID: 24304905
Microfabricated collagen tracks facilitate single cell metastatic invasion in 3D
Kraning-Rush CM, Carey SP, Lampi MC, Reinhart-King CA.
Integr Biol (Camb), 2013, PMID: 23388698
Controlling the mechanical properties of three-dimensional matrices via non-enzymatic collagen glycation
Mason BN, Reinhart-King CA.
Organogenesis, 2013, PMID: 23811696
Substrate Stiffness Regulates PDGF-Induced Circular Dorsal Ruffle Formation Through MLCK
Huynh J, Bordeleau F, Kraning-Rush CM, Reinhart-King CA.
Cell Mol Bioeng, 2013, PMID: 24348877
Arterial stiffening precedes systolic hypertension in diet-induced obesity
Weisbrod RM, Shiang T, Al Sayah L, Fry JL, Bajpai S, Reinhart-King CA, Lob HE, Santhanam L, Mitchell G, Cohen RA, Seta F.
Hypertension, 2013, PMID: 24060894
A physical sciences network characterization of non-tumorigenic and metastatic cells
Physical Sciences - Oncology Centers Network; Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH.
Sci Rep, 2013, PMID: 23618955
Elucidating mechanical transition effects of invading cancer cells with a subnucleus-scaled microfluidic serial dimensional modulation device
Mak M, Reinhart-King CA, Erickson D.
Lab Chip, 2013, PMID: 23212313
Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior
Mason BN, Starchenko A, Williams RM, Bonassar LJ, Reinhart-King CA.
Acta Biomater, 2013, PMID: 22902816
Implanted adipose progenitor cells as physicochemical regulators of breast cancer
Chandler EM, Seo BR, Califano JP, Andresen Eguiluz RC, Lee JS, Yoon CJ, Tims DT, Wang JX, Cheng L, Mohanan S, Buckley MR, Cohen I, Nikitin AY, Williams RM, Gourdon D, Reinhart-King CA, Fischbach C.
Proc Natl Acad Sci U S A, 2012, PMID: 22665775
Mechanobiology of tumor invasion: engineering meets oncology
Carey SP, D'Alfonso TM, Shin SJ, Reinhart-King CA.
Crit Rev Oncol Hematol, 2012, PMID: 22178415
Controlling matrix stiffness and topography for the study of tumor cell migration
Kraning-Rush CM, Reinhart-King CA.
Cell Adh Migr, 2012, PMID: 22863740
Quantifying traction stresses in adherent cells
Kraning-Rush CM, Carey SP, Califano JP, Reinhart-King CA.
Methods Cell Biol, 2012, PMID: 22482948
Cellular traction stresses increase with increasing metastatic potential
Kraning-Rush CM, Califano JP, Reinhart-King CA.
PLoS One, 2012, PMID: 22389710
Inducing apoptosis in rolling cancer cells: a combined therapy with aspirin and immobilized TRAIL and E-selectin
Rana K, Reinhart-King CA, King MR.
Mol Pharm, 2012, PMID: 22724630
Biophysical control of invasive tumor cell behavior by extracellular matrix microarchitecture
Carey SP, Kraning-Rush CM, Williams RM, Reinhart-King CA.
Biomaterials, 2012, PMID: 22405848
Fabrication of substrates with defined mechanical properties and topographical features for the study of cell migration
Charest JM, Califano JP, Carey SP, Reinhart-King CA.
Macromol Biosci, 2012, PMID: 22021131
Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration
Huynh J, Nishimura N, Rana K, Peloquin JM, Califano JP, Montague CR, King MR, Schaffer CB, Reinhart-King CA.
Sci Transl Med, 2011, PMID: 22158860
The role of the cytoskeleton in cellular force generation in 2D and 3D environments
Kraning-Rush CM, Carey SP, Califano JP, Smith BN, Reinhart-King CA.
Phys Biol, 2011, PMID: 21301071
Approaches to manipulating the dimensionality and physicochemical properties of common cellular scaffolds
Bajpai S, Kim NY, Reinhart-King CA.
Int J Mol Sci, 2011, PMID: 22272094
Single cell-mediated collagen reorganization in 3D matrices
Carey SP, Kraning-Rush CM, Reinhart-King CA.
Annu Int Conf IEEE Eng Med Biol Soc, 2011, PMID: 22255298
Microfabricated physical spatial gradients for investigating cell migration and invasion dynamics
Mak M, Reinhart-King CA, Erickson D.
PLoS One, 2011, PMID: 21695222
PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation
Heo KS, Lee H, Nigro P, Thomas T, Le NT, Chang E, McClain C, Reinhart-King CA, King MR, Berk BC, Fujiwara K, Woo CH, Abe J.
J Cell Biol, 2011, PMID: 21624955
How matrix properties control the self-assembly and maintenance of tissues
Reinhart-King CA.
Ann Biomed Eng, 2011, PMID: 21491153
Indentation measurements of the subendothelial matrix in bovine carotid arteries
Peloquin J, Huynh J, Williams RM, Reinhart-King CA.
J Biomech, 2011, PMID: 21288524
Biodegradable functional poly(ester amide)s with pendant hydroxyl functional groups: synthesis, characterization, fabrication and in vitro cellular response
Deng M, Wu J, Reinhart-King CA, Chu CC.
Acta Biomater, 2011, PMID: 21187171
Biological performance of biodegradable amino acid-based poly(ester amide)s: Endothelial cell adhesion and inflammation in vitro
Horwitz JA, Shum KM, Bodle JC, Deng M, Chu CC, Reinhart-King CA.
J Biomed Mater Res A, 2010, PMID: 20629024
Substrate Stiffness and Cell Area Predict Cellular Traction Stresses in Single Cells and Cells in Contact
Califano JP, Reinhart-King CA.
Cell Mol Bioeng, 2010, PMID: 21116436
Synthesis, characterization and cytotoxicity of photo-crosslinked maleic chitosan-polyethylene glycol diacrylate hybrid hydrogels
Zhong C, Wu J, Reinhart-King CA, Chu CC.
Acta Biomater, 2010, PMID: 20416406
Exogenous and endogenous force regulation of endothelial cell behavior
Califano JP, Reinhart-King CA.
J Biomech, 2010, PMID: 19815215
The effects of substrate elasticity on endothelial cell network formation and traction force generation
Califano JP, Reinhart-King CA.
Annu Int Conf IEEE Eng Med Biol Soc, 2009, PMID: 19964074
Synthesis and characterization of biodegradable poly(ester amide)s with pendant amine functional groups and in vitro cellular response
Deng M, Wu J, Reinhart-King CA, Chu CC.
Biomacromolecules, 2009, PMID: 19810736
Endothelial cell adhesion and migration
Reinhart-King CA.
Methods Enzymol, 2008, PMID: 18772010
Physiologic stress-mediated signaling in the endothelium
Reinhart-King CA, Fujiwara K, Berk BC.
Methods Enzymol, 2008, PMID: 18772009
Cell-cell mechanical communication through compliant substrates
Reinhart-King CA, Dembo M, Hammer DA.
Biophys J, 2008, PMID: 18775964
Tensional homeostasis and the malignant phenotype
Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM.
Cancer Cell, 2005, PMID: 16169468
The dynamics and mechanics of endothelial cell spreading
Reinhart-King CA, Dembo M, Hammer DA.
Biophys J, 2005, PMID: 15849250
Dynamic heterodimer-functionalized surfaces for endothelial cell adhesion
Willcox PJ, Reinhart-King CA, Lahr SJ, DeGrado WF, Hammer DA.
Biomaterials, 2005, PMID: 15763255