Publications

  1. Endothelial cells on an aged subendothelial matrix display heterogeneous strain profiles in silico
    Kohn, J.C., T. Abdairahman, K. Sack, T. Frank, C.A. Reinhart-King
    Biomechanics and Modeling in Mechanobiology, 2018, in press.
  2. Determining mechanical features of modulated epithelial monolayers using subnuclear particle tracking.
    Armiger, T.J., M.C. Lampi, C. A Reinhart-King, and K.N. Dahl
    Journal of Cell Science, 2018, in press.
  3. Clinical doses of radiation reduce collagen matrix stiffness.
    Miller, J.P., B.H. Borde, F. Bordeleau, M.R. Zanotelli, D.J. LaValley, D.J. Parker, L.J. Bonassar, S.C. Pannullo, C.A. Reinhart-King
    APL Bioengineering, 2018, 2, 031901.
  4. Beneficial effects of exercise on the subendothelial matrix are short-lived.
    Kohn, J., F. Bordeleau, J.P. Miller, H. Watkins, S. Modi, J. Azar, D.A. Putnam, and C.A. Reinhart-King
    Journal of Biomechanical Engineering, 2018: 140(7), 074501
  5. Eigenstrain as a mechanical set-point of cells.
    Lin S., M.C. Lampi, C.A. Reinhart-King, G. Tsui, J. Wang, C.A. Nelson, L. Gu
    Biomechanics and Modeling in Mechanobiology, 2018, doi: 10.1007/s10237-018-1004-0
  6. Cell migration in microfabricated 3D collagen microtracks is mediated through the prometastatic protein girdin.
    Rahman-Zaman A., S. Shan, C.A. Reinhart-King
    Cellular and Molecular Bioengineering, 2018, 11(1):1-10.
  7. The role of age-related intimal remodeling and stiffening in atherosclerosis.
    VanderBurgh J.A., C.A. Reinhart-King
    Advances in Pharmacology, 2018;81:365-391.
  8. Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials.
    Lampi M.C., C.A. Reinhart-King
    Science Translational Medicine, 2018, 10(422).
  9. High-fat, high-sugar diet-induced subendothelial matrix stiffening is mitigated by exercise.
    Kohn J.C., J. Azar, F. Seta, C.A. Reinhart-King
    Cardiovascular Engineering and Technology, 2018, 9(1):84-93.
  10. Regulation of ATP utilization during metastatic cell migration by collagen architecture.
    Zanotelli M.R., Z.E. Goldblatt, J.P. Miller, F. Bordeleau, J. Li, J.A. VanderBurgh, M.C. Lampi, M.R. King, C.A. Reinhart-King
    Molecular Biology of the Cell, 2018, 29(1):1-9.
  11. Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy.
    Mulligan JA, F. Bordeleau, C.A. Reinhart-King, S.G. Adie
    Biomedical Optics Express, 2017, 8(2):1152-1171.
  12. Three-dimensional collagen matrix induces a mechanosensitive invasive epithelial phenotype.
    Carey S.P., K.E. Martin, C.A. Reinhart-King
    Scientific Reports, 2017, 10;7:42088.
  13. Matrix stiffening promotes a tumor vasculature phenotype.
    Bordeleau F., B.N. Mason, E.M. Lollis, M. Mazzola, M.R. Zanotelli, S. Somasegar, J.P. Califano, C. Montague, D.J. LaValley, J. Huynh, N. Mencia-Trinchant, Y.L. Negrón Abril, D.C. Hassane, L.J. Bonassar, J.T. Butcher, R.S. Weiss, C.A. Reinhart-King
    Proc Natl Acad Sci U S A., 2017, 114(3):492-497.
  14. Matrix stiffness enhances VEGFR-2 internalization, signaling, and proliferation in endothelial cells.
    LaValley, D.J., M.R. Zanotelli, F. Bordeleau, W. Wang, S.C. Schwager, C.A. Reinhart-King
    Convergent Science Physical Oncology, 2017, 3(4), 044001.
  15. Subcellular regulation of cancer cell mechanics.
    Zanotelli, M.R., F. Bordeleau, C.A. Reinhart-King
    Current Opinion in Biomedical Engineering, 2017, 1(1): 8-14.
    *Featured on the cover
  16. The mechanics of single cell and collective migration of tumor cells.
    Lintz, M, A. Muñoz A, C.A. Reinhart-King
    Journal of Biomechanical Engineering, 2017, 1;139(2).
    *Selected as an Editor's Choice
  17. Tuning cell migration: contractility as an integrator of intracellular signals from multiple cues.
    Bordeleau, F., C.A. Reinhart-King
    F1000 Research, 2016, 5. pii: F1000 Faculty Rev-1819.
  18. Local extracellular matrix alignment directs cellular protrusion dynamics and migration through Rac1 and FAK.
    Carey S.P., Z.E. Goldblatt, K.E. Martin, B. Romero, R.M. Williams, C.A. Reinhart-King
    Integrative Biology, 2016, 8(8):821-35.
  19. Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation.
    Desrochers L.M., F. Bordeleau, C.A. Reinhart-King, R.A. Cerione, M.A. Antonyak
    Nature Communications, 2016, 7:11958.
  20. Improving fascin inhibitors to block tumor cell migration and metastasis.
    Han S., J. Huang, B. Liu, B. Xing, F. Bordeleau, C.A. Reinhart-King, W. Li, J.J Zhang, X.Y. Huang
    Molecular Oncology, 2016, 10(7):966-80.
  21. Mechanical heterogeneities in the subendothelial matrix develop with age and decrease with exercise.
    Kohn J.C., A. Chen, S. Cheng, D.R. Kowal, M.R. King, C.A. Reinhart-King
    Journal of Biomechanics, 2016, 49(9):1447-1453.
  22. Vinculin regulates directionality and cell polarity in 2D, 3D matrix and 3D microtrack migration
    Rahman, A.R., S.P. Carey, C.M. Kraning-Rush, Z.E. Goldblatt, F. Bordeleau, M.C. Lampi, D.Y. Lin, A.J. Garcia and C.A. Reinhart-King Molecular Biology of the Cell, 2016, 27(9): 1431–1441.
  23. Simvastatin ameliorates matrix stiffness-mediated endothelial monolayer disruption.
    Lampi, M.C., C.J. Faber, J. Huynh, F. Bordeleau, M.R. Zanotelli, C.A. Reinhart-King
    PLoS One, 2016, 11(1):e0147033.
  24. Manipulation of in vitro collagen matrix architecture for scaffolds of improved physiological relevance.
    Hapach, L.A., J.A. VanderBurgh, J.P. Miller, C.A. Reinhart-King
    Phys Biol., 2015, 12(6):061002.
  25. Self-assembled cationic biodegradable nanoparticles from pH-responsive amino-acid-based poly(ester urea urethane)s and their application as a drug delivery vehicle.
    He, M., A. Potuck, J.C. Kohn, K. Fung, C.A. Reinhart-King, C.C. Chu
    Biomacromolecules, 2016, 17(2):523-37.
  26. Microvesicles released from tumor cells disrupt epithelial cell morphology and contractility.
    Bordeleau, F., B. Chan, M.A. Antonyak, M.C. Lampi, R.A. Cerione, C.A. Reinhart-King
    J Biomech, 2016, 49(8):1272-1279
  27. The 2015 Young Innovators of Cellular and Molecular Bioengineering.
    Reinhart-King C.A., C.E. Schmidt, N.A. Peppas
    Cell Mol Bioeng., 2015, 8(3):305-306.
  28. Tissue stiffness regulates SR protein-mediated splicing of the EDB-fibronectin isoform in tumors
    Bordeleau, F., J.P. Califano, Y.L. Negrón Abril, B.N. Mason, D.J. LaValley, S.J. Shin, R.S. Weiss and C.A. Reinhart-King
    Proc Natl Acad Sci USA, 2015, 112 (27) 8314-8319. 
  29. Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization.
    Huang F-K., S. Han, B. Xing, J. Huang, B. Liu, F. Bordeleau, C.A. Reinhart-King, J.J. Zhang, and X.-Y. Huang
    Nature Communications, 2015, 6:7465. 
  30. Probing the biophysical properties of primary breast tumor-derived fibroblasts.
    Alcoser, T.A., F. Bordeleau, S.P. Carey, M.C. Lampi, D.R. Kowal, S. Somasegar, S. Varma, S.J. Shin, and C.A. Reinhart-King
    Cellular and Molecular Bioengineering, 2015, 8(1):76-85
  31. Age-related vascular stiffening: causes and consequences
    Kohn, J.C.*, M.C. Lampi*, C.A. Reinhart-King
    Frontiers in Genetics, 2015, 6(112):1-17.
    (*denotes equal contribution)
  32. Biophysical induction of vascular smooth muscle cell podosomes.
    Kim, N.Y., J.C. Kohn, J. Huynh, S.P. Carey, B.N. Mason, A.G. Vouyouka, C.A. Reinhart-King
    PLoS One, 2015, 10(3): e0119008.
  33. Comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks.
    Carey S.P., A. Rahman, C.M. Kraning-Rush, B. Romero, S. Somasegar, O.M. Torre, R.M. Williams, C.A. Reinhart-King.
    Am J Physiol Cell Physiol., 2015, 308(6):C436-47.
  34. Cooperative effects of matrix stiffness and fluid shear stress on endothelial cell behavior.
    Kohn, J.C., * D.W. Zhou, * F. Bordeleau, A.L. Zhou, B.N. Mason, M.J. Mitchell, M.R. King, C.A. Reinhart-King
    Biophysical Journal, 2015, 108(3):471-8.
    (*denotes equal contribution)
  35. The young innovators of cellular and molecular bioengineering.
    Reinhart-King, C.A., D.J. Mooney, D.V. Schaffer
    Cellular and Molecular Bioengineering, 2014, 1;7(3):291-292.
  36. Matrix stiffening in the formation of blood vessels.
    LaValley, D.J. and C.A. Reinhart-King
    Advances in Regenerative Biology, 1: 25247
  37. Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro.
    van Oers, R.F., E.G. Rens, D.J. LaValley, C.A. Reinhart-King, R.M. Merks
    PLoS Computational Biology, 2014, 10(8):e1003774.
  38. A microfluidic device to select for cells based on chemotactic phenotype.
    Bajpai, S., M.J. Mitchell, M.R. King, C.A. Reinhart-King
    Technology, 2014, 2(2):101-105.
  39. The rocky road of metastasis: the role of cytoskeletal mechanics in cell migratory response to 3D matrix topography.
    Bordeleau F., T.A. Alcoser, C.A. Reinhart-King
    Am J Physiol Cell Physiol., 2014, 306(2):C110-20.
  40. Arterial stiffening precedes systolic hypertension in diet-induced obesity
    Weisbrod, R.M., T. Shiang, T., L. Al Sayah, J.L. Fry, S. Bajpai, C.A. Reinhart-King, H.E. Lob, L. Santhanam,
    G. Mitchell, R.A. Cohen, F. Seta
    Hypertension, 2013, 62(6):1105-10.
  41. Topographical guidance of 3D tumor cell migration at an interface of collagen densities
    Bordeleau, F., L.N. Tang and C.A. Reinhart-King
    Physical Biology, 2013, 10(6):065004.
  42. Controlling the Mechanical Properties of Three-Dimensional Matrices via Non-Enzymatic Collagen Glycation
    Mason, B. and C.A. Reinhart-King
    Organogenesis, 2013, 9(2): 70-75.
  43. Substrate Stiffness Regulates PDGF-Induced Circular Dorsal Ruffle Formation Through MLCK
    Huyhn, J., F. Bordeleau, C.M. Kraning-Rush, C.A. Reinhart-King
    Cellular and Molecular Bioengineering, 2013, 6(2), 138-147.
  44. A Physical Sciences Network Characterization of Non-Tumorigenic and Metastatic Cells The Physical Sciences–Oncology Network*
    Kraning-Rush, C.M., Reinhart-King, C.A. et al.
    Scientific Reports, 2013, 3:1449. doi: 10.1038/srep01449.
    (*denotes a group of investigators within the NCI-PSOC network who co-authored this article).
  45. Leading Malignant Cells Initiate Collective Epithelial Cell Invasion in a Three- Dimensional Heterotypic Tumor Spheroid Model
    Carey, S.P., A. Starchenko, A.L. McGregor, C.A. Reinhart-King
    Clinical and Experimental Metastasis, 2013, 30(5):615-630.
  46. Microfabricated Collagen Tracks Facilitate Single Cell Metastatic Invasion in 3D
    Kraning-Rush, C.M., S.P. Carey, M.C. Lampi, C.A. Reinhart-King
    Integrative Biology, 2013, 5(3):606-16.
  47. Elucidating Mechanical Transition Effects of Invading Cancer Cells with a Subnucleus-Scaled Microfluidic Serial Dimensional Modulation Device
    Mak, M., C.A. Reinhart-King, D. Erickson
    Lab on a Chip, 2013, 13(3):340-8.
  48. Tuning 3D Collagen Matrix Stiffness Independently of Collagen Concentration Modulates Endothelial Cell Behavior
    Mason, B.N., A. Starchenko, R.M. Williams, L.J. Bonassar, C.A. Reinhart-King
    Acta Biomaterialia, 2012, 2013, 9(1)4635-44.
  49. Matrix Mechanics in the Regulation of Angiogenesis
    Califano, J.P. and C.A. Reinhart-King
    Mechanical and Chemical Signaling in Angiogenesis
    , C.A. Reinhart-King (Ed.), 2013, Springer.
  50. Matrix Stiffness: A Regulator of Cellular Behavior and Tissue Formation
    Mason, B.N., J.P. Califano and C.A. Reinhart-King
    Engineering Biomaterials for Regenerative Medicine, S. Bhatia (Ed.), 2012, Springer.
  51. Inducing Apoptosis in Rolling Cancer Cells: A Combined Therapy with Aspirin and Immobilized TRAIL & E-Selectin
    Rana, K., C.A. Reinhart-King, M.R. King
    Molecular Pharmaceutics
    , 2012, 9 (8), pp 2219–2227.
  52. Controlling matrix stiffness and topography for the study of tumor cell migration
    Kraning-Rush, C.M. and C.A. Reinhart-King
    Cell Adhesion and Migration, 2012, 6(3):274-279.
  53. Implanted adipose progenitor cells as physicochemical regulators of breast cancer
    Brooks, E.M., B.R. Seo, J.P. Califano, R.C. Andresen Eguiluz, J.S. Lee, C.J. Yoon, D.T. Tims, J.X. Wang, L. Cheng, S. Mohanan, M.R. Buckley, I. Cohen, A.Y. Nikitin, R.M. Williams, D. Gourdon, C.A. Reinhart-King, and C. Fischbach,
    Proceedings of the National Academy of Sciences, 2012, 109(25):9786-91.
  54. Mechanobiology of Tumor Invasion: where engineering meets oncology
    Carey, S.P, T.M. D’Alfonso, S.J. Shin, C.A. Reinhart-King
    Clinical Reviews in Oncology and Hematology, 2012, 83(2):170-183.
  55. Quantifying Traction Stresses During Cell Migration
    Kraning -Rush, C.M., S.P. Carey, J.P. Califano and C.A. Reinhart-King,
    Methods in Cell Biology, 2012, 110:139-178.
  56. Biophysical control of invasive tumor cell behavior by extracellular matrix microarchitecture,
    Carey, S.P., C.M. Kraning-Rush, R. Williams, C.A. Reinhart-King
    Biomaterials
    , 2012, 33(16):4157-65.
  57. Cellular Traction Stresses Increase with Increasing Metastatic Potential,
    Kraning-Rush, C.M., J.P. Califano and C.A. Reinhart-King
    PLoS ONE
    , 2012, 7(2): e32572. doi:10.1371/journal.pone.0032572.
  58. Approaches to manipulating the dimensionality and physicochemical properties of common cellular scaffolds
    Bajpai, S., N-Y Kim, C.A. Reinhart-King
    International Journal of Molecular Sciences, 2011;12(12):8596-609.
  59. Fabrication of substrates with defined mechanical properties and topographical features for the study of cell migration
    Charest, J., J.P. Califano, S.P. Carey and C.A. Reinhart-King
    Macromolecular Bioscience
    , 2012, 12(1):12-20.
  60. Single cell-mediated collagen reorganization in 3D matrices,
    Carey S.P., C.M. Kraning-Rush, C.A. Reinhart-King
    Conf Proc IEEE Eng Med Biol Soc., 2011, Aug:4333-5.
  61. How Matrix Properties Control the Self-Assembly and Maintenance of Tissues
    C.A. Reinhart-King
    Annals of Biomedical Engineering, 2011,39(7):1849-56.
  62. Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration
    Huynh, J., K. Rana, N. Nozomi, JM Peloquin, JP Califano, CM Montague, C.B. Schaffer, M.R. King, C.A. Reinhart-King
    Science Translational Medicine, 2011, 3(112):112ra122.
  63. PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation
    Heo, K., H. Lee, P. Nigro, T. Thomas, N. Le, E. Chang, C. McClain, C.A. Reinhart-King, M.R. King, B.C. Berk, K. Fujiwara, C. Woo, J. Abe,
    Journal of Cell Biology, 2011, 193(5):867-84.
  64. Cancer Cell Migration and Metastasis in the Microenvironment: A Tapered Microchannel Approach for Single Cell Studies
    Mak, M., C.A. Reinhart-King and D. Erickson
    Plos One, 2011, 6(6):e20825.
  65. Indentation Measurements of the Subendothelial Matrix in Bovine Carotid Arteries.
    Peloquin, J.M., J. Huynh, R.M. Williams, C.A. Reinhart-King
    Journal of Biomechanics, 2011, 44, 815-821.
  66. The Role of the Cytoskeleton in Cellular Force Generation in 2D and 3D.
    Kraning-Rush C., S.P. Carey, J.P. Califano, B.N. Smith and C.A. Reinhart-King
    Physical Biology, 2011, 8(1):015009
  67. Cell-Generated Forces in Tissue Assembly and Function
    Huynh, J., Calfano, J.P., and C.A. Reinhart-King
    Mechanobiology of Cell-Cell & Cell-Matrix Interactions,
    A.J. Wagoner-Johnson and B. Harley (Ed.) Springer, 2011
  68. Biodegradable Functional Poly(ester amide)s with Pendant Hydroxyl Functional Groups: Synthesis, Characterization, Fabrication and In Vitro Cellular Response.
    Deng M, Wu J, Reinhart-King CA, Chu CC.
    Acta Biomaterialia, 2011, 7(4):1504-15.
  69. Forces During Cell Spreading and Adhesion
    Carey, S, J. Charest, J., and C.A. Reinhart-King
    Studies in Mechanobiology, Tissue Engineering and Biomaterials: Cellular and Biomolecular Mechanics and Mechanobiology

    A. Gefen (Ed.), Springer, 2011.
  70. Synthesis and characterization of functionalized water soluble cationic poly(ester amide)s
    Pang, X., J. Wu, C.A. Reinhart-King, and C.C. Chu
    J. Polym. Sci. Part A: Polymer Chemistry, 2010 48(17): 3758-3766.
  71. Synthesis, Characterization and Cytotoxicity of Photo-Crosslinked Maleic Chitosan– Polyethylene Glycol Diacrylate Hybrid Hydrogels
    Zhong C., J. Wu, C.A. Reinhart-King and C. C. Chu
    Acta Biomaterialia, 2010, 6(10): 3908-3918. 
  72. Biological performance of biodegradable amino acid-based poly(ester amide)s: Endothelial cell adhesion and inflammation in vitro
    Horwitz, J.A., K.M. Shum, J.C. Bodle, M. Deng, C.C. Chu, and C.A. Reinhart-King
    Journal of Biomedical Materials Research, 2010, 95(2):371-80.
  73. Control of cell migration using a conducting polymer device
    Gumus, A. J.P Califano, A.M.D. Wan, J. Huynh, C.A. Reinhart-King and G.G. Malliaras
    Soft Matter, 2010, 6: 5138-5142.
  74. Substrate Stiffness and Cell Area Predict Cellular Traction Stresses in Single Cells and Cells in Contact
    Califano, J.P. and C.A. Reinhart-King
    Cellular and Molecular Engineering, 2010, 3(1): 68-75.  

  75. The effects of substrate elasticity on endothelial cell network formation and traction force generation.
    Califano JP, Reinhart-King CA.
    Conf Proc IEEE Eng Med Biol Soc. 2009;1:3343-5. 
  76. Synthesis and Characterization of biodegradable poly(ester amide)s with pendant amine function groups and in vitro cellular response
    Deng, M., Wu, J., Reinhart-King, CA and C.C. Chu
    Biomacromolecules. 2009, 10(11):3037-47
  77. Exogenous and Endogenous Force Regulation of Endothelial Cells
    Califano, J.P. and C.A. Reinhart-King
    Journal of Biomechanics. 2010, 43(1):79-86 
  78. A Balance of Chemistry and Mechanics Regulates Endothelial Network Formation
    Califano, J.P. and C.A. Reinhart-King
    Cell and Molecular Bioengineering, 2008. 1(2-3): p122-132.
    Selected as an Outstanding Paper within the Cellular and Molecular Engineering Track at the 2008 Annual BMES meeting.
  79. Endothelial Cell Adhesion and Migration
    C.A. Reinhart-King
    Methods in Enzymology, 2008; 443: 45-64.

Early Work

  1. Physiologic Stress-Mediated Signaling in the Endothelium
    Reinhart-King, CA, K. Fujiwara, B.C. Berk
    Methods in Enzymology, 2008; 443:25-44.
  2. Cell-Cell Mechanical Communication through Compliant Substrates
    Reinhart-King, C.A., M. Dembo, and D.A. Hammer
    Biophysical Journal, 2008. 95(12): 6044-51.
  3. Tensional Homeostasis and the Malignant Phenotype
    Paszek, M.J., N. Zahir, K.R. Johnson, J.N. Lakins, G.I. Rozenberg, A. Gefen
    C.A. Reinhart-King, S.S. Margulies, M. Dembo, D. Boettiger, D.A. Hammer, V.M. Weaver
    Cancer Cell, 2005. 8(3): 241-54. (Cover Article)
  4. The Dynamics and Mechanics of Endothelial Cell Spreading
    Reinhart-King, C.A., M. Dembo, and D.A. Hammer
    Biophysical Journal, 2005. 89(1): 676-89.
  5. Traction Forces Exerted by Adherent Cells
    Reinhart-King, C.A. and D.A. Hammer,
    Advances in Cellular Engineering: Understanding the Biomolecular Interface, 2005.
    M.R. King (Ed.), Academic Press, New York: 3-24.
  6. Dynamic Heterodimer-Functionalized Surfaces for Endothelial Cell Adhesion
    Willcox, P.J., C.A. Reinhart-King, S.J. Lahr, and D.A. Hammer
    Biomaterials, 2005. 26(23): 4757-66.
  7. Endothelial Cell Traction Forces on RGD-Derivatized Polyacrylamide Substrata
    Reinhart-King, C.A., M. Dembo, and D.A. Hammer
    Langmuir,
    2003. 19(5): 1573-1579.
  8. The Role of Transient ERK2 Signals in Fibronectin- and Insulin-mediated DNA Synthesis
    Asthagiri, A.R., C.A. Reinhart, A.F. Horwitz, and D.A. Lauffenburger
    Journal of Cell Science, 2000. 113(24): 4499-510.
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